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ID 52488
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Title Alternative
Hox gene and development of the auditory circuit
Author
Narita, Yuichi
Kajari Karmakar
Sébastien Ducret
Filippo M. Rijli
Abstract
Sound vibration is sensed by hair cells in the inner ear. The information is transmitted to the cochlear nucleus in the brainstem via spiral ganglion neurons. The information is further transmitted to higher relaying centers in the brain such as superior olivary complex and inferior colliculus. The connectivity between these components is topographically organized in a frequency-specific manner. It is known that the organization is well-established from the beginning of the circuit development. However, little is still known about the molecular mechanisms underlying the development of connectivity in the auditory circuit. Homeobox transcription factors of the Hox gene family are known for their involvement in early anterior-posterior axis patterning of neuronal progenitors in the hindbrain. Recent evidence indicates that they also play important roles in late aspects of neuronal development and establishment of topographic circuitry. Moreover, a mutation in the HOXA2 gene has been recently shown to be responsible for hearing deficits in humans. By means of spatiotemporally controlled Hoxa2 and Hoxb2 conditional mutations in the mouse we analyzed the involvement of these factors in auditory circuit development and connectivity.
Note
特別講演要旨 (Summary of Special Lecture)
Published Date
2014-04
Publication Title
岡山実験動物研究会報
Publication Title Alternative
Proceedings of Okayama Association for Laboratory Animal Science
Volume
volume30
Publisher
岡山実験動物研究会
Publisher Alternative
Okayama Association for Laboratory Animal Science
Start Page
11
End Page
13
Content Type
Others
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
poalas