FullText URL PLoSONE_0050082.PDF
Author Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko|
Published Date 2012-11-26
Publication Title PLoS ONE
Volume volume7
Issue issue11
Publisher Public Library of Science
Start Page e50082
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 23189181
DOI 10.1371/journal.pone.0050082
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0050082
FullText URL plosone_7_11_e50082.PDF
Author Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko|
Published Date 2012-11-26
Publication Title PLoS ONE
Volume volume7
Issue issue11
Publisher Public Library of Science
Start Page e50082
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 23189181
DOI 10.1371/journal.pone.0050082
Web of Science KeyUT 000311929800058
Related Url https://doi.org/10.1371/journal.pone.0050082
JaLCDOI 10.18926/AMO/54192
FullText URL 70_2_131.pdf
Author Ohuchi, Hideyo| Taniguchi, Kaori| Miyaishi, Satoru| Kono, Hitomi| Fujita, Hirofumi| Bando, Tetsuya| Fuchizawa, Chiharu| Ohtani, Yuko| Ohtani, Osamu|
Abstract Human congenital anomalies provide information that contributes to the understanding of developmental mechanisms. Here we report bilateral optic nerve aplasia (ONA) with microphthalmia in the autopsy of the cadaver of a 70-year-old Japanese female. The gross anatomical inspection of the brain showed a cotton thread-like cord in the presumed location of the optic nerve tract or chiasm. Histologically, no neural retina, optic nerve bundle or retinal central vessels were formed in the eye globe, and the retinal pigment cells formed rosettes. The cornea, iris, and lens were also histologically abnormal. Immunohistochemically, no retinal cells expressed beta III tubulin, and Pax6-immunoreactive cells were present in the ciliary non-pigmented epithelial cells. This case of ONA could be attributed to the agenesis of retinal projection neurons as a sequel to the disruption of neural retina development. The neural retina formation would coordinate the proper development of ocular tissues.
Keywords eye development human congenital anomalies optic nerve aplasia microphthalmia neural retina
Amo Type Case Reports
Published Date 2016-04
Publication Title Acta Medica Okayama
Volume volume70
Issue issue2
Publisher Okayama University Medical School
Start Page 131
End Page 137
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27094838
Web of Science KeyUT 000377626300008