JaLCDOI 10.18926/AMO/32845
FullText URL fulltext.pdf
Author Niimi, Takashi| Yoshinouchi, Takeo| Ohtsuki, Yuji| Fujita, Jiro| Sato, Shigeki| Sugiura, Yoshiki| Ohta, Kazutaka| Kajiura, Motoharu| Ueda, Ryuzo|
Abstract <p>Nonspecific interstitial pneumonia (NSIP) has been recognized as a separate histological classification of interstitial lung disease. Similar features are found not only in idiopathic NSIP, but also in NSIP associated with collagen vascular disorder (CVD-NSIP). We examined the clinical symptoms, laboratory findings, and prognosis of 13 cases of idiopathic NSIP and 11 cases of CVD-NSIP. Immunohistochemical staining was performed using the streptavidin/biotin/peroxidase method with anti-alpha-smooth muscle actin antibody. No differences in the distribution of clinical features, laboratory findings, and prognosis were observed between idiopathic NSIP and CVD-NSIP. In immunohistochemical staining of the fibrosing areas, myofibroblasts were observed in 7 of 13 idiopathic NSIP cases, but in 10 of 11 CVD-NSIP cases. With regards to intra-alveolar organization, myofibroblasts were observed in all 10 CVD-NSIP cases, but they were observed in only 2 of 9 idiopathic NSIP cases. We found a significantly higher myofibroblast proliferation in the intra-alveolar organization of CVD-NSIP compared to idiopathic NSIP. Clinically, idiopathic NSIP and CVD-NSIP are similar, but are pathologically different.</p>
Keywords interstitial pneumonia nonspecific interstitial pneumonia myofibroblast collagen vascular disorder
Amo Type Article
Published Date 2003-02
Publication Title Acta Medica Okayama
Volume volume57
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 38
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12765222
Web of Science KeyUT 000181198200005
JaLCDOI 10.18926/AMO/31702
FullText URL fulltext.pdf
Author Yoshinouchi, Takeo| Ohtsuki, Yuji| Fujita, Jiro| Sugiura, Yoshiki| Banno, Shogo| Sato, Shigeki| Ueda, Ryuzo|
Abstract <p>Pathologic features of Mycoplasma pneumoniae infection (M. pneumonia) are generally non-specific, and the literature regarding the pathologic features of M. pneumonia with intraalveolar exudates is limited. Clinical and histopathological studies were performed in 3 patients with M. pneumonia which did not respond to erythromycin and minocycline, but all rapidly recovered after corticosteroid therapy. In pathologic findings, we observed intraalveolar exudates and focal organization in M. pneumonia, and its intraalveolar lesions were compared between M. pneumonia and bronchiolitis obliterans organizing pneumonia containing fibrin (BOOP). Immunohistochemical studies were performed using the streptavidin biotin peroxidase complex method with anti-alpha-smooth muscle actin antibody and anti-pancytokeratin AE1/AE3 antibody. In pathologic findings, more fibrin deposits in intaalveolar lesions were observed in M. pneumonia than in BOOP. In intaalveolar lesions of M. pneumonia, a larger amount of nuclear debris, more neutrophils, and more erythrocytes were noted. Myofibroblasts were observed in the organization of BOOP, while in the intaalveolar lesions of M. pneumonia, myofibroblasts were not observed. These results suggest that M. pneumonia with intraalveolar exudates responds well to corticosteroid and its intraalveolar lesions apparently differed from those in BOOP.</p>
Keywords exudate fibrin Mycoplasma pneumonia organizing pneumonia steroid therapy
Amo Type Article
Published Date 2002-04
Publication Title Acta Medica Okayama
Volume volume56
Issue issue2
Publisher Okayama University Medical School
Start Page 111
End Page 116
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12002617
Web of Science KeyUT 000175176900008
JaLCDOI 10.18926/AMO/31700
FullText URL fulltext.pdf
Author Yamanouchi, Hideo| Ohtsuki, Yuji| Fujita, Jiro| Bandoh, Shuji| Yoshinouchi, Takeo| Ishida, Toshihiko|
Abstract <p>Leu-7 positive lymphocytes, including natural killer cells, play an important role in the immune system's surveillance function to prevent the development of cancer. The incidence of lung cancer is significantly high in patients with end-stage pulmonary fibrosis. We hypothesized that the number of Leu-7 positive cells may be decreased in areas of severe pulmonary fibrosis. To demonstrate this, Leu-7 positive cells were immunohistochemically stained in 41 lung specimens obtained from patients with idiopathic pulmonary fibrosis and pulmonary fibrosis associated with collagen vascular disorders. The number of Leu-7 positive cells was evaluated according to the pathological findings. In pathologically normal lung, Leu-7 positive cells were mostly found within the capillaries of the septa and rarely in the alveolar space or the stroma. The number of Leu-7 positive cells was 0.69 +/- 0.15 in areas of advanced fibrosis (n = 41), 2.39 +/- 0.60 in areas that had newly developeing fibrosis (n = 41), 1.14 +/- 0.57 in bronchiolitis obliterans organizing pneumonia (n = 9), and 1.35 +/- 0.87 in diffuse alveolar damage (DAD) (n = 11). The number of Leu-7 positive cells in areas of newly developing fibrosis (2.39 +/- 0.60) was significantly higher than that in areas of established fibrosis (0.69 +/- 0.15, P &#60; 0.05). Our present study demonstrates a significant decrease in the number of Leu-7 positive cells in areas of advanced fibrosis. This evidence may partly explain the high incidence of lung cancer associated with pulmonary fibrosis.</p>
Keywords Leu-7 positive cells natural killer cells idiopathic pulmonary fibrosis lung cancer
Amo Type Article
Published Date 2002-04
Publication Title Acta Medica Okayama
Volume volume56
Issue issue2
Publisher Okayama University Medical School
Start Page 83
End Page 89
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12002622
Web of Sience KeyUT 000175176900004