JaLCDOI 10.18926/AMO/30470
FullText URL fulltext.pdf
Author Watanabe, Kazuhide| Matsuka, Naoyuki| Furuno, Katushi| Eto, Kohei| Kawasaki, Hiromu| Gomita, Yutaka|
Abstract <p>In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.</p>
Keywords omeprazole suspension pharmacokinetics rats
Amo Type Article
Published Date 1996-08
Publication Title Acta Medica Okayama
Volume volume50
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 222
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8874584
Web of Science KeyUT A1996VE60800006