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ID 31969
JaLCDOI
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Author
Piao, Cheng-Yu
Fujioka, Shin-ichi
Iwasaki, Yoshiaki ORCID Kakenhi
Fujio, Kozo
Kaneyoshi, Toshihiko
Araki, Yasuyuki
Hashimoto, Kuniaki
Senoh, Tomonori
Terada, Ryo
Nishida, Tomohiro
Kobashi, Haruhiko
Sakaguchi, Kohsaku
Shiratori, Yasushi
Abstract

Lamivudine is widely used to treat patients with hepatitis B. However, the outcomes in patients with hepatocellular carcinoma (HCC) treated with lamivudine have not been established. This study was conducted to evaluate the outcomes of lamivudine treatment for patients with HCC using an untreated, matched control group. Thirty patients with controlled HCC orally received lamivudine. As controls, 40 patients with HCC who were not treated with lamivudine and matched for clinical features were selected. The lamivudine-treated and untreated groups were compared with respect to changes in liver function, HCC recurrence, survival, and cause of death. In the lamivudine-treated group, there was significant improvement in the Child-Pugh score at 24 months after starting treatment, while no improvement was observed in the untreated group. There was no significant difference in the cumulative incidence of HCC recurrence and survival between the groups. However, there was a significant difference in the cumulative incidence of death due to liver failure (P= 0.043). A significant improvement in liver function was achieved by lamivudine treatment, even in patients with HCC. These results suggest that lamivudine treatment for patients with HCC may prevent death due to liver failure. Further prospective randomized studies using a larger number of patients are required.

Keywords
liver failure
Child-Pughscore
recurrence
survival
resistant mutant
Amo Type
Article
Published Date
2005-10
Publication Title
Acta Medica Okayama
Volume
volume59
Issue
issue5
Publisher
Okayama University Medical School
Start Page
217
End Page
224
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT