FullText URL FI_10_17.pdf
Author Ohkura, Takahiro| Yoshimura, Teizo| Fujisawa, Masayoshi| Ohara, Toshiaki| Marutani, Rie| Usami, Kaya| Matsukawa, Akihiro|
Keywords Ras/Raf/ERK/MAPK Spred2 adipocyte inflammation macrophage obesity
Published Date 2019-01-22
Publication Title Frontiers in Immunology
Volume volume10
Publisher Frontiers Media S.A
Start Page 17
ISSN 1664-3224
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2019 Authors
File Version publisher
PubMed ID 30723473
DOI 10.3389/fimmu.2019.00017
Web of Science KeyUT 000456196900002
Related Url isVersionOf https://doi.org/10.3389/fimmu.2019.00017
FullText URL JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg
Author Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki|
Keywords Immunohistochemistry PD-L1 Pancreatic cancer
Note This fulltext will be available in Apr 2020|
Published Date 2019-04-29
Publication Title Journal of Gastroenterology
Volume volume54
Issue issue11
Start Page 1019
End Page 1028
ISSN 09441174
NCID AA10988015
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31032528
DOI 10.1007/s00535-019-01586-6
Web of Science KeyUT 000492169400008
Related Url isVersionOf https://doi.org/10.1007/s00535-019-01586-6
FullText URL K0005596_other1.pdf
Author Thar Htet San| Fujisawa, Masayoshi| Fushimi, Soichiro| Soe, Lamin| Ngu Wah Min| Yoshimura, Teizo| Ohara, Toshiaki| Myint Myint Yee| Oda, Shinsuke| Matsukawa , Akihiro|
Keywords Breast cancer molecular subtypes Ki-67 expression Myanmar
Note 学位審査副論文|
Published Date 2017-06-25
Publication Title Asian Pacific journal of cancer prevention
Volume volume18
Issue issue6
Publisher Asian Pacific Organization for Cancer Prevention
Start Page 1617
End Page 1621
ISSN 1513-7368
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 28670879
DOI 10.22034/APJCP.2017.18.6.1617
Related Url isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521
JaLCDOI 10.18926/AMO/52791
FullText URL 68_4_249.pdf
Author Ogawara, Yuya| Tachibana, Tomoyasu| Orita, Yorihisa| Uchino, Kaori| Wani, Yoji| Nagahiro, Itaru| Matsuyama, Yuko| Abe, Iku| Fujisawa, Masayoshi| Nishizaki, Kazunori|
Abstract We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations.
Keywords tracheal stenosis fibrous foreign body intubation tracheotomy laser
Amo Type Case Report
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 249
End Page 252
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145411
Web of Science KeyUT 000340687500007
JaLCDOI 10.18926/AMO/49258
FullText URL 67_1_61.pdf
Author Tachibana, Tomoyasu| Orita, Yorihisa| Fujisawa, Masayoshi| Ogawara, Yuya|
Abstract Thyroid carcinomas arising from ectopic thyroid tissue are uncommon;most of them arise from thyroid tissue in thyroglossal cysts. A rare case of a 66-year-old woman with papillary thyroid carcinoma arising from median ectopic thyroid tissue lacking a thyroglossal duct remnant is reported. The tumor was resected by Sistrunk's procedure, and the patient's postoperative course was good.
Keywords ectopic thyroid papillary thyroid carcinoma thyroglossal duct remnant
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 61
End Page 64
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439510
Web of Science KeyUT 000316829900008
JaLCDOI 10.18926/AMO/49044
FullText URL 66_6_475.pdf
Author Hase, Soichiro| Mitsumori, Akihito| Inai, Ryota| Takemoto, Mitsuhiro| Matsubara, Shinichiro| Akamatsu, Nobuo| Fujisawa, Masayoshi| Joja, Ikuo| Sato, Shuhei| Kanazawa, Susumu|
Abstract The purpose of this study is to evaluate the diagnostic usefulness of magnetic resonance imaging (MRI) characteristics of endometrial polyps in order to differentiate them from other endometrial lesions. MRI was retrospectively reviewed in 40 patients with pathologically proven endometrial polyps. Special attention was paid to the sizes, shapes, margins, internal structures, signal intensities, and post-contrast enhancement patterns. A central fibrous core, intratumoral cysts, and hemorrhage were seen in 30 (75%), 22 (55%), and 14 (35%) patients, respectively. The predominant signal intensity of the lesions showed iso-to slightly low signal intensity relative to the endometrium on T2-weighted images in 36 (90%), low signal intensity on diffusion-weighted images in 32 (80%), and strong or moderate enhancement on enhanced T1-weighted images in 28 patients (70%), respectively. In 32 (80%) patients, the endometrial polyps showed global or partial early enhancement. On dynamic study, rapid enhancement with a persistent strong enhancement pattern was seen in 17 (42.5%) and a gradually increasing enhancement pattern was seen in 17 patients (42.5%). These MRI features can be helpful to distinguish the endometrial polyps from various other endometrial lesions.
Keywords endometrial polyp central fibrous core intratumoral cyst magnetic resonance imaging (MRI) uterus
Amo Type Original Article
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 475
End Page 485
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254582
Web of Science KeyUT 000312966100007
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/49723
JaLCDOI 10.18926/AMO/32811
FullText URL fulltext.pdf
Author Fujisawa, Masayoshi| Notohara, Kenji| Tsukayama, Choutatsu| Mizuno, Ryuichirou| Okada, Shigeru|
Abstract <p>We observed the distribution of CD56+ epithelial cells in the pancreatic duct system using 25 fetal, one infantile, 3 normal adult, 4 diabetic, and 8 chronically inflamed pancreatic tissue samples. In the early stage of gestation (12 to 17 weeks), CD56+ cells were commonly seen in the immature tubular structures. They were often continuous to pancreatic islets, and their distribution was similar to that of synaptophysin (Syn)+ cells, suggesting that they are precursors of islet neogenesis. Their number decreased in proportion to gestational age. Instead, from 24 weeks of gestation, luminal cell clusters that were common in interlobular ducts revealed CD56+. These cell clusters were unrelated to islet neogenesis and Syn expression. Similar CD56+ luminal cell clusters were also observed in cases of chronic pancreatitis, whereas they were scarce in normal adult and diabetic tissues. CD56+ cells were also occasionally seen in intralobular ducts, intercalated ducts, and centroacinar cells in cases of chronic pancreatitis. We conclude that there are two types of CD56+ epithelial cells in the pancreatic duct system: CD56+ endocrine cells are numerous during the early stage of gestation, when islet neogenesis appears, while CD56+ luminal cells may represent developmental and regenerative changes of pancreatic ducts.</p>
Keywords CD56 pancreas development pancreatitis islets
Amo Type Article
Published Date 2003-12
Publication Title Acta Medica Okayama
Volume volume57
Issue issue6
Publisher Okayama University Medical School
Start Page 279
End Page 284
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14726964
Web of Science KeyUT 000187556500002
JaLCDOI 10.18926/AMO/31687
FullText URL fulltext.pdf
Author Mizote, Akiko| Hida, Akira I| Hosako, Mutsumi| Fujisawa, Masayoshi| Kamekawa, Mika| Okada, Shigeru|
Abstract <p>The ferric nitrilotriacetate-induced carcinogenesis model is unique in that reactive oxygen species-free radicals are involved in the carcinogenic process. But the effects of iron-withdrawal in the progression of renal cell carcinoma are not well understood. We performed repeated phlebotomies on animals that had been administered ferric nitrilotriacetate in the initiation stage of renal cell carcinoma (phlebotomy group), and compared the development of renal tumors with those not receiving repeated phlebotomies (non-phlebotomy group). Ferric nitrilotriacetate-treated male Wistar rats were randomly divided into 2 groups: a phlebotomy group (21 rats) and a non-phlebotomy group (17 rats). Ten age-adjusted normal rats were also observed as a normal group. Hematocrit was maintained under 25% in the phlebotomy group. Hematocrit levels in the normal group and in the non-phlebotomy group were not significantly different. As a result, the incidence of renal cell carcinoma was not significantly different between phlebotomy and non-phlebotomy animals. However, the total weight of the renal cell carcinoma was significantly heavier in the animals from non-phlebotomy group than in those from the phlebotomy group (23.64 g +/- 18.54 vs. 54.40 g +/- 42.40, P &#60; 0.05). The present study demonstrated that phlebotomy after the administration of ferric nitrilotriacetate did not reduce the incidence of renal cell carcinoma. In addition, we showed that iron withdrawal at the promotion stage of carcinogenesis will retard tumor growth.</p>
Keywords ferric nitrilotriacetate renal cell carcinoma phlebotomy
Amo Type Article
Published Date 2002-08
Publication Title Acta Medica Okayama
Volume volume56
Issue issue4
Publisher Okayama University Medical School
Start Page 199
End Page 204
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12199525
Web of Sience KeyUT 000177382600005