JaLCDOI 10.18926/AMO/31596
FullText URL fulltext.pdf
Author Miyamoto, Osamu| Itano, Toshifumi| Fujisawa, Mutsuo| Tokuda, Masaaki| Matsui, Hideki| Nagao, Seigo| Hatase, Osamu|
Abstract <p>Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were administered into the rat brain following unilateral fimbria-fornix transection. Both bFGF and NGF stimulated the sprouting of acetylcholinesterase (AChE) positive fibers in the hippocampus on the lesioned side. Furthermore, a small number of AChE-positive fibers were regenerated even when only the vehicle was administered. Rats treated with NGF as well as control group had only thin fibers, whereas those treated with bFGF had not only thin fibers but also thick fibers. These results indicate that intrinsic NGF is released and acts on damaged neurons directly, while bFGF acts them on directly and/or indirectly after brain injury.</p>
Keywords bFGF NGF regeneration acetylcholinesterase positive fibers sprouting
Amo Type Article
Published Date 1993-06
Publication Title Acta Medica Okayama
Volume volume47
Issue issue3
Publisher Okayama University Medical School
Start Page 139
End Page 144
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8379341
Web of Sience KeyUT A1993LL12400001