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ID 18915
Eprint ID
18915
FullText URL
Thumnail 70_1341.pdf 308 KB
Title Alternative
Nitrogen Metabolism of the Brain Part 10 Influences of Tranquilizers on Ammonia and Amino Acids in the Rat Brain
Author
Fujita, Shoji
Abstract
In the case of meprobamate application and reserpine injection as tranquilizing treatment, the content of ammonia in the brain was determined by Conwy's micro-diffusion method while that of amino acid by paper chromatography; and the following results were obtained: 1) After meprobamate application per os (1g. per dose), the contents of ammonia. glutamic acid and γ-amino-butylic acid decreased, while those of glutamine and aspartic acid increased. 2) In the group given meprobamate for successive days (350 mg-400 mg/kg), the content of ammonia increased, whereas those of glutamic acid, glutamine, γ-amino-butylic acid and aspartic acid less markedly. 3) In the case of reserpine injection (0.4 mg./kg), ammonia decreased markedly and glutamic acid and γ-amino-butylic acid less markedly. 4) In the group receiving reserpine injections for successive days (0.025 mg/kg/day), the content of ammonia showed a decrease, while that of aspartic acid an increase.
Published Date
1958-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1341
End Page
1345
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/4/70_4_1341/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma