Author Wakamori, Takaaki| Agari, Takashi| Yasuhara, Takao| Kameda, Masahiro| Kondo, Akihiko| Shinko, Aiko| Sasada, Susumu| Sasaki, Tatsuya| Furuta, Tomohisa| Date, Isao|
Published Date 2014-04
Publication Title Parkinsonism and Related Disorders
Volume volume20
Issue issue4
Content Type Journal Article
JaLCDOI 10.18926/AMO/32835
FullText URL fulltext.pdf
Author Mishima, Nobuya| Tamiya, Takashi| Matsumoto, Kengo| Furuta, Tomohisa| Ohmoto, Takashi|
Abstract <p>Radiation damage to normal brain tissue induced by interstitial irradiation with iridium-192 seeds was sequentially evaluated by computed tomography (CT), magnetic resonance imaging (MRI), and histological examination. This study was carried out in 14 mature Japanese monkeys. The experimental area received more than 200-260 Gy of irradiation developed coagulative necrosis. Infiltration of macrophages to the periphery of the necrotic area was seen. In addition, neovascularization, hyalinization of vascular walls, and gliosis were found in the periphery of the area invaded by the macrophages. All sites at which the vascular walls were found to have acute stage fibrinoid necrosis eventually developed coagulative necrosis. The focus of necrosis was detected by MRI starting 1 week after the end of radiation treatment, and the size of the necrotic area did not change for 6 months. The peripheral areas showed clear ring enhancement with contrast material. Edema surrounding the lesions was the most significant 1 week after radiation and was reduced to a minimum level 1 month later. However, the edema then expanded once again and was sustained for as long as 6 months. CT did not provide as clear of a presentation as MRI, but it did reveal similar findings for the most part, and depicted calcification in the necrotic area. This experimental model is considered useful for conducting basic research on brachytherapy, as well as for achieving a better understanding of delayed radiation necrosis.</p>
Keywords interstitial brachytherapy radiation damage normal monkey brain computed tomography (CT) magnetic resonance imaging(MRI)
Amo Type Article
Published Date 2003-06
Publication Title Acta Medica Okayama
Volume volume57
Issue issue3
Publisher Okayama University Medical School
Start Page 123
End Page 131
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12908010
Web of Science KeyUT 000183816500004
JaLCDOI 10.18926/AMO/31645
FullText URL fulltext.pdf
Author Maeda, Yasuhiko| Matsumoto, Kengo| Mizumatsu, Shinichiro| Tamiya, Takashi| Furuta, Tomohisa| Ohmoto, Takashi|
Abstract <p>The effect of intracarotid infusion of etoposide on the permeability of the blood-brain barrier (BBB) and brain-tumor barrier (BTB) was investigated using a model of rats injected with C6 glioma cells. Fifty four glioma-bearing rats were divided into 3 groups and treated with 0, 3, or 15 mg/kg of etoposide infused into the internal carotid artery. BBB or BTB permeability was evaluated qualitatively by the leakage of Evans blue (6 animals in each group) or quantitatively by the diffusion of carboplatin [cis-diammine (1,1-cyclobutane-dicarboxylato) platinum(II); CBDCA] (12 animals in each group) into the normal brain or the tumor tissue. BBB and BTB disruption augmented significantly in proportion to the dose of etoposide. The degree of disruption of BTB was greater than that of BBB, but the rate of disruption of BBB in proportion to increasing the dose of etoposide was higher than that in the BTB. Histopathologically, no obvious changes were observed in the animals of either the control group or the 3 mg/kg group but degenerative changes in the neurons of the hippocampus of the infused hemisphere were seen in the 15 mg/kg group. This change is thought to be caused by apoptosis because of the positive reaction with TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method. Our results suggest that intracarotid infusion of etoposide can increase drug delivery of concurrent antitumor agents into tumor tissue, but cerebral parenchymal cell damage is expected with a higher dosage of etoposide. Therefore, the dosage of etoposide for intracarotid infusion should be lower than 15 mg/kg in order to reduce neurotoxicity of both etoposide and concurrent anticancer drugs.</p>
Keywords etoposide intracarotid infusion blood-brain barrier blood-tumor barrier apoptosis
Amo Type Article
Published Date 1999-02
Publication Title Acta Medica Okayama
Volume volume53
Issue issue1
Publisher Okayama University Medical School
Start Page 5
End Page 11
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000078897700002
JaLCDOI 10.18926/AMO/30670
FullText URL fulltext.pdf
Author Harada, Yasuhiro| Tabuchi, Kazuo| Moriya, Yoshio| Furuta, Tomohisa| Kishikawa, Hidemi| Nishimoto, Akira|
Abstract <p>The amount of S-100 protein in rat brain embolized with carbon microspheres decreased in parallel with the development of cerebral edema as judged by water content, recovering to the normal range by 24h after embolization. These results suggest the participation of S-100 protein in the permeability characterisitics of nervous system capillaries known as the blood-brain barrier.</p>
Keywords S-100 protein blood-brain barrier cerebral edema
Amo Type Article
Published Date 1982-12
Publication Title Acta Medica Okayama
Volume volume36
Issue issue6
Publisher Okayama University Medical School
Start Page 447
End Page 451
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7158426
Web of Sience KeyUT A1982PW07500003