Author Iwamoto, Takayuki| Fujisawa, Tomomi| Shien, Tadahiko| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Takao, Shintaro| Nishimura, Reiki| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| aira, Naruto|
Keywords Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title Breast Cancer
Publisher Springer
ISSN 13406868
NCID AA1103354X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32394413
DOI 10.1007/s12282-020-01095-y
Web of Science KeyUT 000531780600002
Related Url isVersionOf
JaLCDOI 10.18926/AMO/32310
FullText URL fulltext.pdf
Author Emdadul, Haque M| Fujisawa, Tomomi| Yamamoto, Masamichi| Ohmori, Shinji|
Abstract <p>We present here a reliable and sensitive method for the determination of acidic opines such as meso-alanopine, beta-alanopine, tauropine and strombine in biological samples. Interfering primary amino acids were eliminated by reaction with o-phthalaldehyde, and the derivatized compounds were passed through Sep-Pak Plus PS-1 cartridges. The acidic opines were recovered by flushing the cartridges with water, then determined by high performance liquid chromatography after a second derivatization with phenylisothiocyanate. All 4 acidic opines were detected within 30 min. This method ensured good separation and guaranteed almost full recovery of all acidic opines. This method was applied to analyze opines in marine animals and to test whether opines are metabolized in the livers of the rat and fish.</p>
Keywords opines high-performance liquid chromatography determination marine animals phenylisothiocyanate Sep-Pak cartridge
Amo Type Article
Published Date 2000-02
Publication Title Acta Medica Okayama
Volume volume54
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10709616
Web of Science KeyUT 000085526000001