JaLCDOI 10.18926/AMO/31093
FullText URL fulltext.pdf
Author Masuda, Shusaku| Watanabe, Hironobu| Morioka, Masaaki| Fujita, Yukitoshi| Ageta, Tomiko| Kodama, Hiroyuki|
Abstract <p>Both prolidase and prolinase from the human prostate were separated into two peaks by TSK DEAE-5PW chromatography. These peaks of prolidase isozymes I and II differed from each other in their responses to preincubation with Mn2+, their substrate specificity, optimal pH, and heat stability. The molecular weights of prolidases I and II were estimated to be 110,000 and 165,000, respectively, by gel filtration. Substrate specificity of prolinase peaks I and II was almost the same, but they differed in optimal pH and heat stability. The molecular weights of prolinases I and II were about 85,000 and 63,000, respectively. These results indicate that two isozymes of prolidase and of prolinase, which differ in various characteristics, are present in the human prostate.</p>
Keywords human prostate prolidase prolinase
Amo Type Article
Published Date 1994-08
Publication Title Acta Medica Okayama
Volume volume48
Issue issue4
Publisher Okayama University Medical School
Start Page 173
End Page 179
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7817771
Web of Science KeyUT A1994PE51400001
JaLCDOI 10.18926/AMO/30559
FullText URL fulltext.pdf
Author Asahi, Toshihiko| Matsumura, Yosuke| Tanahashi, Toyoko| Yoshimoto, Jun| Kaneshige, Tetsuzo| Fujita, Yukitoshi| Ohmori, Hiroyuki|
Abstract Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences of bladder tumors. Fifty-six patients who were given no preventive treatment against recurrences were taken as the control group. The patients in this series presented at the Okayama University Hospital between 1961 and 1976 and only the first recurrence after the primary operation was taken into consideration. There was no significant difference in the recurrence rates of the control and instillation groups.
Keywords bladder tumor intravesical instillation thiotepa recurrence rate.
Amo Type Article
Published Date 1980-02
Publication Title Acta Medica Okayama
Volume volume34
Issue issue1
Publisher Okayama University Medical School
Start Page 43
End Page 49
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6446839
Web of Sience KeyUT A1980JS13800006