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ID 18001
Eprint ID
18001
FullText URL
Thumnail 82_447.pdf 1.36 MB
Title Alternative
Failure of lipid peroxidation reaction in ascites hepatoma cells (AH-130) and its mechanism
Author
Goto, Nobuyuki
Abstract
Various tissue homogenates can produce lipid peroxide during incubation with Fe(++) or Co(++) in the presence of oxygen. But the homogenate of actively growing cells diminishes or fails to elicit the lipid peroxide formation. In the present report the author studied the mechanism of the failure of lipid peroxidation reaction of ascites hepatoma cells (AH-130) and the following results were obtained. 1. One of the facts of failure of lipid peroxidation reaction was the reduced arachidonic acid content in phospholipid fraction of ascites hepatoma cells. 2. The other facter was the presence of an inhibitor of lipid peroxidation in acetone soluble fraction of the ascites hepatoma cell membrane fractions. Therefore, the phospholipid fraction of the ascites hepatoma cells shows the lipid peroxidation reaction by the treatment with Fe(++). 3. The inhibitor was also found in the acetone soluble fraction of normal rat liver cells but the content was quite low. 4. The chemical nature of the inhibitor was different from the well known, antioxidant such as α-tocopherol, Coenzyme Q and Vitamin K. The chemical structure has not been identified yet, On the basis of these data the author discussed about the mechanism of the regulation of lipid peroxidation reaction in the cells with respect to the regulation of cell growth and cancer cell specificity and to the aging.
Published Date
1970-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume82
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
447
End Page
458
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/82/11-12/82_11-12_447/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma