このエントリーをはてなブックマークに追加
ID 31135
JaLCDOI
FullText URL
Thumnail fulltext.pdf 1.86 MB
Author
Takahashi, Yuhiko
Hashizume, Hiroyuki
Inoue, Hajime
Ogura, Takashi
Abstract

Excised extensor retinacula of the first compartment and tenosynovium from 35 patients (6 men and 29 women) with de Quervain's disease were examined by light and electron microscopy to investigate the pathogenic mechanism. The patients, aged from 22-78 years, averaging 50 years, comprised the study group. Two hundred and thirty-two specimens from cadavers of 95 men and 75 women were macroscopically examined as the control. In the study group, the extensor retinaculum and tenosynovium were macroscopically thickened, and were histologically classified into 4 groups based on presence or absence of septum, and the location of retinacular thickening. Morphologically, the thickening of the tenosynovium and retinaculum was due to fibrosis in every layer, although fibroses were seen mainly in the middle layer. The ratios of proliferation of fibroblasts, myxoid changes and/or hyaline degeneration, and vascular proliferation were varied between layers. Minimal round cell infiltration was found in the retinaculum as well as in the tenosynovium. The results also indicate that the Iwahara-Nozue test can be used to accurately predict relatively greater thickening of the retinaculum on the extensor pollicis brevis side. Based on clinicopathological analyses, it appears that de Quervain's disease is induced not only by extrinsic factors such as superficial friction but also by intrinsic factors.

Keywords
de Quervain's disease
stenosing tenosynovitis
ultrastructural study
histopathology
Amo Type
Article
Published Date
1994-02
Publication Title
Acta Medica Okayama
Volume
volume48
Issue
issue1
Publisher
Okayama University Medical School
Start Page
7
End Page
15
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT