JaLCDOI 10.18926/AMO/31008
FullText URL fulltext.pdf
Author Saito, Daiji| Ueeda, Masayuki| Hina, Kazuyoshi| Watanabe, Hirofumi| Mima, Tsutomu| Hasui, Masahiro| Yamada, Nobuyuki| Haraoka, Shoichi| Tsuji, Takao|
Abstract <p>The effect of the heart rate and myocardial contractile force on the extravascular resistance to blood flow of the left anterior descending coronary artery (LAD) was evaluated in 15 mongrel dogs anesthetized with sodium pentobarbital. The LAD was maximally dilated by intracoronary infusion of adenosine, which precluded the influence of vasomotor tone. Increases in the heart rate and myocardial contractile force decreased coronary blood flow in the absence of a change in coronary perfusion pressure. The changes in mean coronary resistance showed a significant linear relationship to changes in developed tension. The changes in coronary resistance caused by varying the heart rate and contractile force were so small that a normal coronary vascular tree could easily compensate for the increase in resistance. However, it is supposed that with critical stenosis of the vascular tree even a small increase in resistance might cause deleterious effects on coronary blood flow.</p>
Keywords contractile force tachycardia extravascular resistance coronary flow adenosine
Amo Type Article
Published Date 1988-12
Publication Title Acta Medica Okayama
Volume volume42
Issue issue6
Publisher Okayama University Medical School
Start Page 335
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3239438
Web of Science KeyUT A1988R743300005