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ID 30482
JaLCDOI
FullText URL
Author
Satoh, Yasumasa
Higashi, Toshihiro
Shiota, Tetsuya
Kinugasa, Nobuyuki
Yoshida, Keigo
Uematsu, Shuji
Nakatsukasa, Harushige
Nishimura, Yukio
Tsuji, Takao
Abstract

Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity, immunohistochemical staining, and clinical tumor progression was investigated. Cathepsin B activity in adenocarcinomas was significantly elevated compared with that in the tumor-bearing tissue. Furthermore, the tumor/tumor-bearing tissue (T/Tb) ratio of the activity was significantly higher than that of colorectal adenoma. Immunohistochemical studies demonstrated intense staining in the cancerous tissue. With respect to the clinical stage of tumors, the activity tended to be higher in tumors that had invaded the serosa or subserosa than in those that invaded the proper muscle. The results suggest that cathepsin B participates in the progression of human colorectal cancer, and its increased expression is a sensitive marker of the differentiation between colorectal adenoma and adenocarcinoma.

Keywords
cathepsin B
colorectal cancer
colorectal adenoma
Amo Type
Article
Published Date
1996-12
Publication Title
Acta Medica Okayama
Volume
volume50
Issue
issue6
Publisher
Okayama University Medical School
Start Page
305
End Page
311
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT