JaLCDOI 10.18926/AMO/31623
FullText URL fulltext.pdf
Author Sugimoto, Yukio| Iba, Yoshionori| Ishizawa, Keisuke| Suzuki, Genzo| Kamei, Chiaki|
Abstract <p><p>The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.</p></p>
Keywords levocabastine guinea pig lung fragment lipid mediator
Amo Type Brief Note
Published Date 1999-12
Publication Title Acta Medica Okayama
Volume volume53
Issue issue6
Publisher Okayama University Medical School
Start Page 271
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10631382
Web of Science KeyUT 000084414300005