JaLCDOI 10.18926/AMO32719
FullText URL fulltext.pdf
Author Kimura, Ikuro| Takahashi, lsao| Sugiyama, Motoharu|
Abstract <p>The appearance of sideroblasts in hypoplastic anemia (HAl and acute myelocytic leukemia (AML), together with their sideroblastograms, was studied. Hematological studies on cases with type III sideroblast dominance by sideroblastograms produced the following results. Type III sideroblast dominant HA was observed in three of 63 cases. Two of the above three cases had what we call &#34;atypical factor&#34;, while the remaining one became AML in its clinical course and could be considered to be leukemia in a hypoplastic preleukemic stage. Type III sideroblast dominant AML was noted in five of 32 cases. Three of these five cases are compatible with low percentage leukemia, and one of the above three cases showed ringed sideroblasts exhibiting erythroleukemia in the terminal stage. In HA and AML, type III sideroblast dominant cases have to be examined in relation to atypical HA and atypical leukemia. Changes of iron meta. bolism in erythroblasts with preleukemic stage will be attributable to disturbance of erythropoiesis such as erythroid hyperplasia in bone marrow and also, in part, to disturbance of hemoglobin synthesis.</p>
Amo Type Article
Published Date 1974-06
Publication Title Acta Medica Okayama
Volume volume28
Issue issue3
Publisher Okayama University Medical School
Start Page 173
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4280229
NAID 120002312181
JaLCDOI 10.18926/AMO/32699
FullText URL fulltext.pdf
Author Kimura, Ikuro| Onoshi, Taisuke| Yasuhara, Shozo| Watanabe, Tatsuo| Sugiyama, Motoharu| Hiraki, Kiyoshi|
Abstract <p>The streptococcal preparation, OK.432, with predominant host-mediated mode of action, was studied. By giving OK-432 to mice intraperitoneally prior to transplantation of Ehrlich carcinoma, a host-mediated action to increase life-span was clearly confirmed. Pretreatment with OK-432 was also effective against the development of Rauscher leukemia. The host-mediated action of OK-432 varied with the interval between its pretreatment and the inoculation of tumor cells. The effect was most marked when the transplant was performed immediatedly after the pretreatment, and became less marked when the transplant was made one week and two weeks after pretreatment. The host-mediated action can be observed even with a single dose of pretreatment, and becomes more potent as pretreatment was given repeatedly. The host-mediated action was weakened by concomitant pretreatment with cyclophosphamide or roentgen irradiation, and the mechanisms of such action was supposed to be associated with the function of the reticulo-endothelial system.</p>
Amo Type Article
Published Date 1974-12
Publication Title Acta Medica Okayama
Volume volume28
Issue issue6
Publisher Okayama University Medical School
Start Page 423
End Page 431
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4142361
NAID 120002311799
JaLCDOI 10.18926/AMO/32697
FullText URL fulltext.pdf
Author Kimura, Ikuro| Onoshi, Taisuke| Takano, Junko| Osawa, Hiroshi| Yasuhara, Shozo| Watanabe, Tatsuo| Sugiyama, Motoharu|
Abstract <p>Antitumor effects of the combination chemotherapy with hemolytic streptococcus preparation, OK-432, and various anticancer agents were observed on experimental tumors and human cancers. Experimental studies revealed that combined use of OK-432 with Mitomycin C, Nitrogen mustard N-Oxide or Bleomycin was remarkably effective on rodent transplantable tumors such as Ehrlich carcinoma, sarcoma-lOO and rat ascitic hepatoma AH-66. As for the mode of action of OK-432, besides a direct action on cancer cells, a host-mediated action appears to be also involved. Clinical trials were made on 14 cases with various advanced cancers, and favorable response was obtained in 5 with lung cancer. Fever was the major side effect of OK-432 and there was no evidence of bone marrow suppression.</p>
Amo Type Article
Published Date 1974-12
Publication Title Acta Medica Okayama
Volume volume28
Issue issue6
Publisher Okayama University Medical School
Start Page 411
End Page 421
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4142360
NAID 120002311973
JaLCDOI 10.18926/AMO/32676
FullText URL fulltext.pdf
Author Hosoya, Shigee| Kataoka, Mikio| Nakata, Yasunari| Maeda, Tsuyoshi| Nishizaki, Hiroshi| Hioka, Tohru| Mori, Yoshihiro| Ejiri, Tougo| Shiomi, Katsuhiko| Ueoka, Hiroshi| Numata, Takeyuki| Nishii, Kenji| Kodani, Tsuyoshi| Moritani, Yoshiaki| Ohnoshi, Taisuke| Kimura, Ikuro|
Abstract <p>Clinical features were studied in 125 patients with sarcoidosis (72 females and 53 males) diagnosed at Okayama University Hospital during a recent 10-year period. The age distribution had two peaks in patients in their 20s and the 50s. Over half of the patients were detected at health screening check and were asymptomatic, while the remaining were symptomatic. Twelve patients were in stage 0, 41 were in stage I, 54 were in stage II, 16 were in stage III, and 2 were in stage IV according to the chest x-ray findings. Serum angiotensin converting enzyme levels and serum lysozyme levels were elevated in 60% and 76% of the patients, respectively. The bronchoalveolar lavage fluid showed lymphocytosis, especially of helper T-cells. The clinical features of sarcoidosis appear to depend on the duration of the disease.</p>
Keywords sarcoidosis serum angiotesin converting enzyme bronchoalveolar lavage
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 36
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561903
Web of Science KeyUT A1992HH01700006
JaLCDOI 10.18926/AMO/32675
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro|
Abstract The improvement of ventilatory function by spa therapy was examined in 37 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. All subjects had been on long-term corticosteroid therapy before spa therapy. Spa therapy was found to improve the values of ventilatory parameters. The percent improvement in all subjects was +4.1% in %FVC, +8.9% in FEV1.0%, +9.8% in %PEFR, +22.0% in %MMF, +19.7% in %V50 and +28.2% in %V25, respectively. Relating to clinical asthma types, moderate improvement in %MMF and %V25 from 16.7% to 16.9% was observed in type Ia cases, and marked increase in %MMF, %V50 and %V25 was observed from 42.2% to 43.2% in type Ib cases. However, no significant increase was found in these parameters of types Ia or Ib after spa therapy. In patients with type II, a significant increase was shown in %V50 (p less than 0.05) and %V25 (p less than 0.01) after spa therapy. The results show that spa therapy improves the condition of small airways disorder in patients with SDIA.
Keywords spa therapy bronchial asthma ventilatory function small airways
Amo Type Article
Published Date 1992-06
Publication Title Acta Medica Okayama
Volume volume46
Issue issue3
Publisher Okayama University Medical School
Start Page 175
End Page 178
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1502922
Web of Science KeyUT A1992JB50400005
JaLCDOI 10.18926/AMO/32669
FullText URL fulltext.pdf
Author Takigawa, Nagio| Ohnoshi, Taisuke| Ueoka, Hiroshi| Kiura, Katsuyuki| Kimura, Ikuro|
Abstract <p>An etoposide-resistant subline, SBC-3/ETP, from a human small cell lung cancer cell line, SBC-3, was developed by continuous exposure to increasing concentrations of etoposide in culture. The SBC-3/ETP was 52.1-fold more resistant to etoposide than the parent cell line. The SBC-3/ETP was highly cross-resistant to teniposide, adriamycin, vinca alkaloids, 4-hydroperoxycyclophosphamide, CPT-11 and mitomycin C, and marginally cross-resistant to cisplatin, while the subline showed a collateral sensitivity to bleomycin. Topoisomerase I activity in the SBC-3/ETP was reduced to an extent of one half and topoisomerase II activity to an extent of one eighth in comparison with those of the SBC-3. Intracellular accumulation of [3H]-etoposide in the SBC-3/ETP was significantly lower in comparison to the SBC-3. An overexpression of MDR1 mRNA, and the presence of its product, P-glycoprotein, were detected in the SBC-3/ETP by Northern blotting and flowcytometry using a monoclonal antibody of the protein, MRK16. These results indicate that a decreased activity of topoisomerase II is the major factor for the development of etoposide resistance, and that an overexpression of the MDR1 gene is responsible, in part, for the development of resistance to the drug and some structurally unrelated compounds such as adriamycin and vinca alkaloids.</p>
Keywords small cell lung cancer etoposide-resistant cell line P-glycoprotein topoisomerase
Amo Type Article
Published Date 1992-06
Publication Title Acta Medica Okayama
Volume volume46
Issue issue3
Publisher Okayama University Medical School
Start Page 203
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1354408
Web of Science KeyUT A1992JB50400009
JaLCDOI 10.18926/AMO/32659
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro|
Abstract <p>Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).</p>
Keywords asthma asthma syndrome classification by pathophysiology classification by mechanism of onset
Amo Type Article
Published Date 1992-10
Publication Title Acta Medica Okayama
Volume volume46
Issue issue5
Publisher Okayama University Medical School
Start Page 381
End Page 387
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1442158
Web of Science KeyUT A1992JX49500009
JaLCDOI 10.18926/AMO/32631
FullText URL fulltext.pdf
Author Takigawa, Nagio| Ohnoshi, Taisuke| Ueoka, Hiroshi| Kiura, Katsuyuki| Kimura, Ikuro|
Abstract <p>In an attempt to predict the clinical activity of newly developed anthracycline analogues, ME2303, KRN8602, and SM5887 in the treatment of lung cancer, we compared antitumor activity of these drugs with that of adriamycin, using six human lung cancer cell lines and two drug-resistant human lung cancer sublines. Taking the pharmacokinetic data into consideration, we evaluated the relative antitumor activity: the ratio of area under the concentration-time curve of each drug to the 50% inhibitory concentration of the drug. Regarding this ratio, ME2303 was more potent than adriamycin, SM5887, and KRN8602. Cross-resistance of the new analogues to adriamycin was investigated using an adriamycin-resistant small cell lung cancer subline, SBC-3/ADM100 and an etoposide-resistant subline, SBC-3/ETP. SBC-3/ADM100 being 106-fold more resistant to adriamycin than the parent SBC-3 showed less resistance to the analogues: 1.80-fold to KRN8602, 3.80-fold to SM5887, and 8.60-fold to ME2303. SBC-3/ETP which was 52.1-fold more resistant to etoposide and 39.5-fold more resistant to adriamycin were also less resistant to the new analogues: 3.27-fold to KRN8602, 9.07-fold to SM5887, and 17.3-fold to ME2303. In conclusion, ME2303 was found to be the most potent agent among drugs tested for the treatment of lung cancer, and KRN8602 can be expected to be beneficial for the treatment of drug-resistant small cell lung cancer.</p>
Keywords new anthracycline analogues ME2303 KRN8602 SM5887 lung cancer cell line
Amo Type Article
Published Date 1992-08
Publication Title Acta Medica Okayama
Volume volume46
Issue issue4
Publisher Okayama University Medical School
Start Page 249
End Page 256
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1442149
Web of Sience KeyUT A1992JL44200004
JaLCDOI 10.18926/AMO/32622
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Ochi, Koji| Harada, Hideo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract Twenty-one patients with atopic asthma were classified into three types according to their symptoms (clinical diagnosis): Ia, simple bronchoconstriction; Ib, bronchoconstriction + hypersecretion; and II, bronchiolar obstruction, and this classification was compared with a classification made according to clinical findings and examinations (score diagnosis). Type Ib asthma was characterized by the increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF), while type II was characterized by ventilatory dysfunction in small airways and the increased incidence of neutrophils in BALF. Four patients, whose expectoration was between 50 and 99ml/day, of the 12 with type Ia assessed by clinical diagnosis were evaluated as type Ib by score diagnosis. One patient with type II by clinical diagnosis was assessed as questionable type II by score diagnosis. In the other 16 patients, the clinical and score diagnoses were the same.
Keywords bronchial asthma classification ventilatory function cellular composition of BALF sore diagnosis
Amo Type Article
Published Date 1992-08
Publication Title Acta Medica Okayama
Volume volume46
Issue issue4
Publisher Okayama University Medical School
Start Page 295
End Page 301
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1442153
Web of Science KeyUT A1992JL44200010
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Published Date 1963
Publication Title Acta Medicinae Okayama
Volume volume17
Issue issue5
Content Type Journal Article
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Published Date 1963
Publication Title Acta Medicinae Okayama
Volume volume17
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/AMO/32564
FullText URL fulltext.pdf
Author Kimura, Ikuro| Moritani, Yoshiaki| Nishizaki, Yoshitomo| Tanizaki, Yoshiro|
Abstract <p>Changes of basophil leucocyte counts of the peripheral blood in bronchial asthma were investigated mainly by our improved method of KOVACS (4). The results are as follows. I) The basophils in bronchial asthma generally show a higher count than in healthy controls. 2) During the interval of repeated asthmatic attacks the basophil count is higher than in the asymptomatic period. 3) Particularly in an episode of asthmatic attack, the basophils increase immediately before the attack and decrease to the normal level or lower after the attack has begun. 4) During asthmatic attacks it may be possible to expect another attack, if the basophil count again tends to increase from the previous low count. 5) This counting method of basophils is easy enough for the routine examination like calculation of peripheralleucocytes. 6) Observation of the changes of peripheral basophils appears to be a useful laboratory aid for the diagnosis and therapeutic evaluation of bronchial asthma, making possible an early detection of the next attack. A discussion is given of the behavior of the basophils in bronchial asthma.</p>
Amo Type Article
Published Date 1968-08
Publication Title Acta Medicinae Okayama
Volume volume22
Issue issue4
Publisher Okayama University Medical School
Start Page 203
End Page 208
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4239563
NAID 120002311835
JaLCDOI 10.18926/AMO/32487
FullText URL fulltext.pdf
Author Kimura, Ikuro| Yamana, Masatoshi|
Abstract <p>Non-hemin iron content in gastric juice was examined in 46 patients with various blood diseases, especially idiopathic hypochromic anemia and in 26 healthy controls. 1. The iron content in gastric juice was found to be 290 &#956;g/ dl in healthy controls, a lower value of 110 &#956;g/ dl in idiopathic hypochromic anemia and a higher value of 550 &#956;g / dl in aplastic anemia. These values were in a close correlation with serum iron or sideroblasts. 2. In idiopathic hypochromic anemia there was also a close correlation between the iron content in gastric juice and hemoglobin. In the course of treating idiopathic hypochromic anemia (stage of recovery of anemia) the iron content in gastric juice showed a marked increase over the value in healthy controls as well as a transient increase after an intravenous iron tolerance test. This condition may be interpreted as an &#34;iron-losing anemia&#34;. Iron excretion of gastric mucosa in various blood diseases and its changes in the course of treating idiopathic hypochromic anemia in relation to the cause of this anemia were discussed.</p>
Amo Type Article
Published Date 1967-08
Publication Title Acta Medicinae Okayama
Volume volume21
Issue issue4
Publisher Okayama University Medical School
Start Page 177
End Page 183
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4230849
NAID 120002311578
JaLCDOI 10.18926/AMO/32475
FullText URL fulltext.pdf
Author Kimura, Ikuro| Tsuchida, Junichiro| Kodani, Hidenari|
Abstract <p>For the investigation of iron metabolism in the intestinal mucosa in various&#12288;blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls&#12288;and 35 cases with various blood diseases. The following are&#12288;the results&#12288;of the studies on distribution of stainable&#12288;iron, amounts of non-hemin iron in the&#12288;biopsied materials, and iron uptake of the intestinal epithelial cells.&#12288;1) An evaluation of distribution of stainable iron by Berlin&#12288;blue reaction&#12288;showed none or very mild degree, if any,&#12288;inhealthy controls, an increase in&#12288;aplastic anemia,&#12288;pernicious anemia, some of leukemias and in iron deficiency anemia following iron therapy, and a decrease in&#12288;idiopathic hypochromic anemia, anchylostomiasis anemia,&#12288;anemia with cancer, myxedema, hemolytic anemia,&#12288;and in&#12288;some of leukemias. Some of anemia with cancer, however,&#12288;showed an&#12288;increase of a certain degree. In iron absorption tests, no changes were found other than a very mild increase in aplastic anemia. 2) Non-hemin iron was 70-112&#947;/g in healthy controls, increased in aplastic anemia approximately to 100-200&#947;/g, ranging 40-130&#947;/g in leukemia, and decreased in idiopathic hypochromic anemia and in anemia with cancer ranging 30-60&#947;/g and 30-50&#947;/g respectively. Amounts of non-hemin iron and serum iron or sideroblasts show a fair correlation. The fractionation of nonhemin iron in aplastic anemia didn't show any difference in relationship of each fraction from healthy controls despite the increased amount in the former. 3) A radioautographic evaluation of iron uptake by intestinal epithelium was performed by our device for evaluation of intestinal absorption capacity. The iron uptake was mild in healthy controls, almost none in aplastic anemia, and marked in iron deficiency anemia where it was decreased approximately to the level of healthy controls following iron therapy. 4) The intestinal tissue iron showed a series of changes similar to those of iron present in the serum or erythroblasts, and the non-hemin iron in the intestinal mucosa is inversely correlated with iron uptake of epithelium and is considered to regulate the absorption according to its amount.</p>
Amo Type Article
Published Date 1964-06
Publication Title Acta Medicinae Okayama
Volume volume18
Issue issue3
Publisher Okayama University Medical School
Start Page 127
End Page 137
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14222356
NAID 120002311468
JaLCDOI 10.18926/AMO/32466
FullText URL fulltext.pdf
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Abstract <p>Eleven cases of malignant lymphomas were treated with a fibroblast-inhibiting agent, chloroquine, and of these, one case of lymphosarcoma, two of acute and chronic lymphocytic leukemia, respectively, and two of giant follicle lymphoma showed regression of the enlarged lymph nodes and also of the enlarged spleen in some of the splenomegalic patients. In contrast, the drug proved ineffective in two cases of reticulum cell sarcoma and Hodgkin's disease, respectively. The side effects of the drug were minimal, and three of the 11 cases complained of nausea, anorexia or palpebral ptosis, which disappeared by decreasing the drug dosage or combining ATP preparation. The tissue culture study of biopsied lymph nodes from lymphocytic leukemia showed inhibition of the growth zone in a medium containing chloroquine indicating a possibility of the drug action not only upon the stromal tissue but also upon the parenchymal tumor cell.</p>
Amo Type Article
Published Date 1964-04
Publication Title Acta Medicinae Okayama
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 87
End Page 92
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14204462
NAID 120002311940
JaLCDOI 10.18926/AMO/32465
FullText URL fulltext.pdf
Author Hiraki, Kiyoshi| Kimura, Ikuro|
Abstract <p>A fibroblast-inhibiting agent, chloroquine, used in the treatment of animal tumors led to a reasonably good result, and this approach was extended to the treatment of human cancers. Of histologically proven 54 cases, the drug was effective in 38, ineffective in 15, and unknown in one. It proved to be effective in all the patients who were treated for over 2 months with exception of terminal patients. Of the various malignant tumors treated, excellent therapeutic effects were obtained in patients with carcinoma of the lung and bladder. In the cases where the drug was effective there were a decrease of the size of tumors, fall of serum lactic dehydrogenase, increase of necrosis, inhibition of the stroma, as well as improvement of the symptoms and general condition. As to the mechanisms of the drug action, it would be necessary to consider of its anti-inflammatory and humoral effects upon the host in addition to its inhibitory action on the stromal connective tissue of cancers. The present chloroquine treatment appears to have its indication in inoperable cases, and pre- and post-operative cases, and for the prevention of reccurrence of tumors. Studies are currently in progress in our laboratory to discover more potent fibroblastinhibiting agents and on the combined chemotherapy of chloroquine and other anti-turnor agents. We are indebted to the Department of Urology of our University for the generosity to allow us to use the clinical data on patients with cancer of the urinary bladder.</p>
Amo Type Article
Published Date 1964-04
Publication Title Acta Medicinae Okayama
Volume volume18
Issue issue2
Publisher Okayama University Medical School
Start Page 71
End Page 86
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14204461
NAID 120002311710
JaLCDOI 10.18926/AMO/32443
FullText URL fulltext.pdf
Author Tanaka, Toshio| Yamamoto, Michiko| Tamura, Tetsuo| Moritani, Yoshiaki| Miyai, Masahiro| Hiraki, Shunkichi| Ohnoshi, Taisuke| Kimura, Ikuro|
Abstract <p>In order to increase the accuracy of diagnosis in lung cancer, analysis concerning cytological and histological correlation was attempted. The present study consists of 106 patients, who were seen during the past approximately five years and underwent radical surgery to remove tumors completely; mere biopsy specimens were excluded. These patients were 63 years old on the average, 78 males and 28 females, 29 cases of the hilar type (H) and 77 of the peripheral type (P), and 27 and 76 cases of the clinical stage I in H and P, respectively. Histologically, there were 53 adenocarcinomas (Ad), 38 squamous cell carcinomas (Sq), 4 adenosquamous cell carcinomas (Ad + Sq), 5 large cell carcinomas (LCC), and 6 small cell carcinomas (SCC); among them, 3 Ad and 21 Sq in H, and 50 Ad and 17 Sq in P. The overall positive percentages were 65.5 (H) and 26.0 (P) by combination of spontaneous, airsol-induced and Saccomanno's methods, against 96.6 (H) and 72.8 (P) with inclusion of brushing method. 94.8% of Sq in H and 66.7% of Ad and 70.6% of Sq in P were positive by the brushing. A comparative study of these four methods, performed at least once on the same patient, also confirmed the superiority of brushing. Cyto- and histological agreement was 21/21 (100%) for Sq in H, whereas 30/34 (88.2%) for Ad and 13/15 (86.7%) for Sq in P. In conclusion, cyto- and histological findings in H and P corresponded well, and as far as cytology of peripheral type is concerned, a combined method, especially with brushing, is strongly recommended.</p>
Keywords primary lung cancer cytology histology
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 11
End Page 19
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6846050
Web of Science KeyUT A1983QD83600002
JaLCDOI 10.18926/AMO/32436
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Ohtani, Jun| Kimura, Ikuro| Akagi, Katsumi| Townley, Robert G|
Abstract <p>45Ca uptake and histamine release was examined in mast cells from rats sensitized with ovalbumin and Bordetella Bertussis as an adjuvant. The uptake of 45Ca by the mast cells was significantly increased by stimulation with ovalbumin as was the release of histamine from the mast cells. Nifedipine, a calcium antagonist, inhibited the increase in both 45Ca uptake and histamine release stimulated by ovalbumin, though the effect on 45Ca uptake was stronger than that on histamine release.</p>
Keywords mast cells Ca2+ uptake histamine release Ca2+ antagonist
Amo Type Article
Published Date 1983-06
Publication Title Acta Medica Okayama
Volume volume37
Issue issue3
Publisher Okayama University Medical School
Start Page 207
End Page 211
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6192686
Web of Science KeyUT A1983QW75400004
JaLCDOI 10.18926/AMO/32430
FullText URL fulltext.pdf
Author Harada, Hideo| Hayashi, Toshiaki| Miki, Hiroshi| Miyake, Hirofumi| Ochi, Kozi| Kimura, Ikuro| Takeda, Masahiko| Tanaka, Juntaro| Tanaka, Toshio|
Abstract <p>Sulfated acidic mucopolysaccharides have been found to be significant components of &#34;protein plugs&#34; in patients with chronic pancreatitis. The precise identification of the mucopolysaccharides and their distribution within the protein plugs may clarify the pathogenesis of the plugs. Pure pancreatic juice from five patients with chronic pancreatitis was obtained by endoscopic retrograde catheterization of the papilla of Vater. Enzymes for digestion of the plugs included hyaluronidase of the bovine testes and streptomyces hyalurolyticus, chondroitinase ABC and AC, and sialidase (neuraminidase). Our study indicated that: I) Sialic acid is distributed throughout the plugs and may be a major component, followed by a lesser amount of chondroitin sulfate B. 2) Chondroitin sulfate A, C, D and E and chondroitin may be minor components. 3) Hyaluronic acid is negligible in the plugs.</p>
Keywords chronic pancreatitis pure pancreatic juice protein plugs enzyme-histochemistry
Amo Type Article
Published Date 1983-06
Publication Title Acta Medica Okayama
Volume volume37
Issue issue3
Publisher Okayama University Medical School
Start Page 227
End Page 231
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6224398
Web of Science KeyUT A1983QW75400006
JaLCDOI 10.18926/AMO/32429
FullText URL fulltext.pdf
Author Takahashi, Isao| Kohi, Fumikazu| Inagaki, Noritoshi| Ohmoto, Eijiro| Fukumoto, Mitsuhiro| Watanabe, Seiichiro| Takaoka, Kazuko| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
Abstract <p>The O2- production by neutrophils was examined in 4 cases of refractory anemia with excess of blasts (RAEB) in order to evaluate the possible causes of enhanced susceptibility to infection and to gain some informations on the differentiation of neutrophils in this hematological disorder. In three of the four RAEB cases there was little O2- production by neutrophils, in addition to there being morphological anomalies of the neutrophils such as a Pelger-Huet-like anomaly, granular deficiency and binucleated cells. These results suggest that the impairment of O2- production by neutrophils in RAEB is one of the possible causes of susceptibility to infection and also suggest that the differentiation of neutrophils in this hematological disorder is faulty. The estimation of O2- production by neutrophils may be a useful diagnostic method for preleukemia.</p>
Keywords superoxide anion refractory anemia with excess of blasts (RAEB) preleukemia
Amo Type Article
Published Date 1983-10
Publication Title Acta Medica Okayama
Volume volume37
Issue issue5
Publisher Okayama University Medical School
Start Page 417
End Page 421
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6316758
Web of Science KeyUT A1983RN98400005