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ID 56203
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Takamura, Hiroyoshi Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Ohashi, Takumi Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kikuchi, Takahiro Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Endo, Noriyuki Himeji EcoTech Co., Ltd.
Fukuda, Yuji Himeji EcoTech Co., Ltd.
Kadota, Isao Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Abstract
Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 0.30-1.31 μg mL-1. These results show that hybridization of the geraniol and butenolide structural motifs resulted in the enhancement of the antifouling activity.
Note
This is an Accepted Manuscript of an article published by Royal Society of Chemistry
We are grateful to Okayama Foundation for Science and Technology and The Yakumo Foundation for Environmental Science for financial support.
Published Date
2017-06-13
Publication Title
Organic and Biomolecular Chemistry
Volume
volume15
Issue
issue26
Publisher
Royal Society of Chemistry
Start Page
5549
End Page
5555
ISSN
14770520
NCID
AA1168650X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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isVersionOf https://doi.org/10.1039/c7ob01160a