JaLCDOI 10.18926/AMO/30401
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Author Ogulener, Nuran| Larabal, Eda| Baysal, Firuz| Dikmen, Atilla|
Abstract <p>The possible role of nitric oxide (NO) and vasoactive intestinal polypeptide on isoprenaline-induced relaxation of the mouse longitudinal gastric fundal strips precontracted with 5.4 x 10(-7) M carbachol was investigated. Isoprenaline (5 x 10(-7) M, 10(-6) M and 5 x 10(-6) M) produced a concentration-dependent relaxations. NG-nitro L-arginine (10(-4) M) partly inhibited isoprenaline-induced relaxation. The inhibitory action of NG-nitro L-arginine was reversed by 4 x 10(-4) M L-arginine but not by 4 x 10(-4) M D-arginine. NG-nitro L-arginine (10(-4) M) did not affect the relaxation caused by sodium nitroprusside (10(-6) M). Vasoactive intestinal polypeptide antibody 7913 (1:160 dilution) partly inhibited isoprenaline-induced relaxation. This inhibition was greater on the response to the higher isoprenaline concentration (5 x 10(-6) M) than to the lower concentration (10(-6) M). The combination of vasoactive intestinal polypeptide antibody and NG-nitro L-arginine significantly enhanced the inhibition on 10(-6) M isoprenaline action. These results suggest that nitric oxide and vasoactive intestinal polypeptide may partly contribute to the relaxation induced by isoprenaline in the mouse gastric fundus precontracted with carbachol.</p>
Keywords isoprenaline N<sub>G<sub>-nitro L-arginine(L-NOARG) L-arginine(L-ARG) D-arginine(D-ARG) vasoactive intestinal polypeptide (VIP) antibody 7913 isolated mouse gastric fundus
Amo Type Article
Published Date 1995-10
Publication Title Acta Medica Okayama
Volume volume49
Issue issue5
Publisher Okayama University Medical School
Start Page 231
End Page 236
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8585392
Web of Science KeyUT A1995TC51800001