FullText URL K0005592_other1.pdf
Author Hinamoto, Norikazu| Maeshima, Yohei| Yamasaki, Hiroko| Nasu, Tatsuyo| Saito, Daisuke| Watatani, Hiroyuki| Ujike, Haruyo| Tanabe, Katsuyuki| Masuda, Kana| Arata, Yuka| Sugiyama, Hitoshi| Sato, Yasufumi| Makino, Hirofumi|
Note 学位審査副論文
Published Date 2014-09-25
Publication Title Plos One
Volume volume9
Issue issue9
Publisher Public Library of Science
Start Page e107934
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/
File Version publisher
PubMed ID 25255225
DOI 10.1371/journal.pone.0107934
Web of Sience KeyUT 000344862300045
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0107934 isPartOf http://ousar.lib.okayama-u.ac.jp/55517
FullText URL Nat_Rev_Nephrol_12_1_13.pdf Nat_Rev_Nephrol_12_1_13_image.pdf
Author Wada, Jun| Makino, Hirofumi|
Note This is an Accepted Manuscript of an article published by Nature Publishing Group|
Published Date 2016-01
Publication Title Nature Reviews Nephrology
Volume volume12
Issue issue1
Publisher Nature Publishing Group
Start Page 13
End Page 26
ISSN 1759-5061
NCID AA12392934
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26568190
DOI 10.1038/nrneph.2015.175
Web of Science KeyUT 000367758500005
Related Url isVersionOf https://doi.org/10.1038/nrneph.2015.175
Author Wakabayashi, Hiroshi| Ito, Toshihiro| Fushimi, Soichiro| Nakashima, Yuki| Itakura, Jyunya| Liu, Qiuying| Win, Min Min| Sun, Cuiming| Chen, Cao| Sato, Miwa| Mino, Megumi| Ogino, Tetsuya| Makino, Hirofumi| Yoshimura, Akihiko| Matsukawa, Akihiro|
Published Date 2012-09
Publication Title Clinical Immunology
Volume volume144
Issue issue3
Content Type Journal Article
Author Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi|
Published Date 2012-07
Publication Title Journal of Clinical Endocrinology & Metabolism
Volume volume97
Issue issue7
Content Type Journal Article
JaLCDOI 10.18926/AMO/47261
FullText URL 65_6_363.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r=-0.232, p=0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men.
Keywords abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification
Amo Type Original Article
Published Date 2011-12
Publication Title Acta Medica Okayama
Volume volume65
Issue issue6
Publisher Okayama University Medical School
Start Page 363
End Page 367
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22189476
Web of Science KeyUT 000298516900002
JaLCDOI 10.18926/AMO/47015
FullText URL 65_5_329.pdf
Author Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi|
Abstract It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR=4.50, 95%CI=1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids.
Keywords infection rheumatic disease glucocorticoids interstitial pneumonia risk factors
Amo Type Original Article
Published Date 2011-10
Publication Title Acta Medica Okayama
Volume volume65
Issue issue5
Publisher Okayama University Medical School
Start Page 329
End Page 334
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22037270
Web of Science KeyUT 000296116400007
Author Tsukamoto, Naoko| Otsuka, Fumio| Miyoshi, Tomoko| Inagaki, Kenichi| Nakamura, Eri| Suzuki, Jiro| Ogura, Toshio| Iwasaki, Yasumasa| Makino, Hirofumi|
Published Date 2011-01-30
Publication Title Molecular and Cellular Endocrinology
Volume volume332
Issue issue1-2
Content Type Journal Article
JaLCDOI 10.18926/AMO/46850
FullText URL 65_4_247.pdf
Author Watanabe, Naomi| Shikata, Kenichi| Shikata, Yasushi| Sarai, Kei| Omori, Kazuyoshi| Kodera, Ryo| Sato, Chikage| Wada, Jun| Makino, Hirofumi|
Abstract Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. We examined the expression of ICAM-1 in the kidneys of experimental diabetic rats. Human glomerular endothelial cells (GE cells) were exposed to normal glucose concentration, high glucose concentration (HG), or high mannitol concentration (HM), and then the expression of the ICAM-1 protein and the phosphorylation of the 3 subfamilies of mitogen-activated protein kinase (MAPK) were determined using Western blot analysis. Next, to evaluate the involvement of MAPKs in HG- or HM-induced ICAM-1 expression, we preincubated GE cells with the inhibitors for ERK, p38 or JNK 1h prior to the application of glucose or mannitol. Expression of ICAM-1 was increased in the glomeruli of diabetic rats. Both HG and HM induced ICAM-1 expression and phosphorylation of ERK1/2, p38 and JNK in GE cells. Expression of ICAM-1 was significantly attenuated by inhibitors of ERK, p38 and JNK. We conclude that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions.
Keywords diabetic nephropathy ICAM-1 ERK p38 MAPK JNK
Amo Type Original Article
Published Date 2011-08
Publication Title Acta Medica Okayama
Volume volume65
Issue issue4
Publisher Okayama University Medical School
Start Page 247
End Page 257
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21860531
Web of Science KeyUT 000294236700005
JaLCDOI 10.18926/AMO/45272
FullText URL 65_2_129.pdf
Author Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi|
Abstract A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome.
Keywords computed tomography diabetes mellitus emphysematous cystitis
Amo Type Case Report
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519371
Web of Science KeyUT 000289818800009
JaLCDOI 10.18926/AMO/45266
FullText URL 65_2_81.pdf
Author Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi|
Abstract Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease.
Keywords kidney inflammation chemokine
Amo Type Original Article
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 81
End Page 89
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519365
Web of Science KeyUT 000289818800003
JaLCDOI 10.18926/AMO/40510
FullText URL 64_5_339.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r=-0.306, p=0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women.
Keywords systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification
Amo Type Short Communication
Published Date 2010-10
Publication Title Acta Medica Okayama
Volume volume64
Issue issue5
Publisher Okayama University Medical School
Start Page 339
End Page 343
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2010 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20975768
Web of Science KeyUT 000283563300010
JaLCDOI 10.18926/AMO/40128
FullText URL 64_4_213.pdf
Author Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi|
Abstract Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.
Keywords adrenal cortex angiotensin II aldosterone bone morphogenetic protein
Amo Type Review
Published Date 2010-08
Publication Title Acta Medica Okayama
Volume volume64
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 218
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20802537
Web of Science KeyUT 000281384400001
JaLCDOI 10.18926/AMO/40013
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and metabolic syndrome in Japanese. A total of 11,711 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation. From this group, we further investigated the data on 1,576 subjects. eGFR was calculated using serum creatinine (Cr), age and sex. The diagnosis of metabolic syndrome was based on the Japanese criteria. In the first analysis, 288 men (7.8%) and 498 women (6.2%) were diagnosed with reduced eGFR (<60ml/min). eGFR was not correlated with anthropometric, body composition parameters in either sex. In the second analysis, in subjects without medications, 132 men (20.8%) and 15 women (1.6%) were diagnosed with metabolic syndrome. eGFR was lower in men with abdominal obesity and in women with hypertension was than in those without. Among Japanese not taking medications, lower eGFR may be a characteristic of men with abdominal obesity and of women with hypertension.
Keywords metabolic syndrome estimated glomerular filtration rate (eGFR) abdominal circumference
Amo Type Original Article
Published Date 2010-06
Publication Title Acta Medica Okayama
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 203
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596132
Web of Sience KeyUT 000279094300007
Author Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Miyoshi, Tomoko| Kano, Yoshihiro| Goto, Junko| Ogura, Toshio| Makino, Hirofumi|
Published Date 2008-06-25
Publication Title Endocrinology
Volume volume149
Issue issue6
Content Type Journal Article
JaLCDOI 10.18926/AMO/32912
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Matsumoto, Sumiko| Makino, Hirofumi| Numata, Takeyuki|
Abstract <p>We compared the levels of hepatic enzymes in 220 Japanese men with metabolic syndrome with those in age and sex-matched subjects without the syndrome. Metabolic syndrome was defi ned by the new criteria published in Japan, and hepatic enzymes, i.e., aspartate aminotransferase (AST), alanine aminotransferase (ALT) and &#947;-glutamyl transpeptidase (&#947;GTP), were measured. AST, ALT and &#947;GTP in subjects with metabolic syndrome were signifi cantly higher than those in subjects without the syndrome, and metabolic syndrome was closely associated with hepatic enzymes in this cohort of Japanese men.</p>
Keywords metabolic syndrome hepatic enzymes
Amo Type Short Communication
Published Date 2007-02
Publication Title Acta Medica Okayama
Volume volume61
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 34
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17332839
Web of Science KeyUT 000244432400004
JaLCDOI 10.18926/AMO/32900
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Wada, Jun| Matsumoto, Sumiko| Nishikawa, Hidetaka| Makino, Hirofumi| Numata, Takeyuki|
Abstract We re-evaluated the criteria for waist circumference to predict the accumulation of the components of metabolic syndrome. We used data for 3,185 Japanese, aged 20-79 years. Metabolic syndrome has recently been redefined by a new criterion in Japan, in which waist circumference cutoff points, i.e. 85 cm for men and 90 cm for women, are employed. Among the 3,185 Japanese considered in the present study, 335 men (26.8%) and 69 women (3.6%) were diagnosed as having metabolic syndrome. A cutoff point as a predictor for 2 or more components of metabolic syndrome was evaluated by sensitivity/specificity and a receiver operating characteristic (ROC) curve. The optimal point was estimated as being approximately 85 cm of waist circumference in men and 75 cm in women. We therefore recommend a cutoff value, 75 cm of waist circumference, for the criterion of metabolic syndrome in women.
Keywords metabolic syndrome waist circumference sensitivity specifi city receiver operating characteristic (ROC) curve
Amo Type Short Communication
Published Date 2007-06
Publication Title Acta Medica Okayama
Volume volume61
Issue issue3
Publisher Okayama University Medical School
Start Page 167
End Page 169
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17593953
Web of Science KeyUT 000247574700006
JaLCDOI 10.18926/AMO/32895
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Saito, Takeshi| Wada, Jun| Nishikawa, Hidetaka| Matsumoto, Sumiko| Miyachi, Motohiko| Fujii, Masafumi| Makino, Hirofumi| Numata, Takeyuki|
Abstract <p>We evaluated the linkage between oxygen uptake at the ventilatory threshold (VT) and muscle strength in subjects with and without metabolic syndrome. We used data of 226 Japanese men with metabolic syndrome and 265 Japanese men without the syndrome. Metabolic syndrome has recently been defined by a new criterion in Japan. Oxygen uptake at VT and muscle strength, i.e. grip strength and leg strength were measured. Oxygen uptake at VT and muscle strength/body weight were found to be significantly lower in subjects with metabolic syndrome than in those without the syndrome. However, the differences did not reach significant levels after adjusting for leg strength/body weight or oxygen uptake at VT. A combination of aerobic exercise and resistance training might be considered for preventing and improving metabolic syndrome.</p>
Keywords metabolic syndrome oxygen uptake ventilatory threshold muscle strength
Amo Type Original Article
Published Date 2007-10
Publication Title Acta Medica Okayama
Volume volume61
Issue issue5
Publisher Okayama University Medical School
Start Page 255
End Page 259
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17971842
Web of Science KeyUT 000250431700003
JaLCDOI 10.18926/AMO/32883
FullText URL fulltext.pdf
Author Miyatake, Nobuyuki| Wada, Jun| Saito, Takeshi| Nishikawa, Hidetaka| Matsumoto, Sumiko| Miyachi, Motohiro| Makino, Hirofumi| Numata, Takeyuki|
Abstract <p>We compared muscle strength between Japanese men with and without metabolic syndrome. We used data for 323 Japanese men with metabolic syndrome and 893 Japanese men without the syndrome. Metabolic syndrome was defined by a new criterion in Japan, and the parameters for muscle strength, i.e. grip strength, leg strength were measured. Leg strength was found to be significantly higher in subjects with metabolic syndrome than in those without, while muscle strength per body weight was significantly lower in subjects with the syndrome. Lower muscle strength per body weight may be one of the characteristic features in subjects with metabolic syndrome.</p>
Keywords metabolic syndrome grip strength leg strength
Amo Type Short Communication
Published Date 2007-04
Publication Title Acta Medica Okayama
Volume volume61
Issue issue2
Publisher Okayama University Medical School
Start Page 89
End Page 102
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17471310
Web of Science KeyUT 000245875600007
JaLCDOI 10.18926/AMO/32882
FullText URL fulltext.pdf
Author Yano, Ryusuke| Yamanura, Masahiro| Sunahori, Katsue| Takasugi, Kouji| Yamana, Jiro| Kawashima, Masanori| Makino, Hirofumi|
Abstract <p>CD16+ monocytes, identified as a minor population of monocytes in human peripheral blood, have been implicated in several inflammatory diseases, including rheumatoid arthritis (RA). Fractalkine (FKN, CX3CL1), a member of the CX3 C subfamily, is induced by pro-inflammatory cytokines, while a receptor for FKN, CX3CR1, is capable of mediating both leukocyte migration and firm adhesion. Here, we investigated the role of FKN and CX3CR1 in activation of CD16+ monocytes and their recruitment into synovial tissues in RA patients. High levels of soluble FKN were detected in the synovial fluid and sera of RA patients. Circulating CD16+ monocytes showed a higher level of CX3CR1 expression than CD16- monocytes in both RA patients and healthy subjects. High level expression of CX3CR1 was also seen in CD16+ monocytes localized to the lining layer in RA synovial tissue. In the in vitro culture experiments, IL-10 induced CX3CR1 expression on the surface of monocytes, and TNFalpha induced membrane-bound FKN as well as soluble FKN expression in synovial fibroblasts. Moreover, soluble FKN was capable of inducing IL-1beta and IL-6 by activated monocytes. These results suggest that FKN might preferentially mediate migration and recruitment of CD16+ monocytes, and might contribute to synovial tissue inflammation.</p>
Keywords CD16 monocytes fractalkine CX3CR1 rheumatoid arthritis
Amo Type Original Article
Published Date 2007-04
Publication Title Acta Medica Okayama
Volume volume61
Issue issue2
Publisher Okayama University Medical School
Start Page 89
End Page 98
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 17471309
Web of Science KeyUT 000245875600006
JaLCDOI 10.18926/AMO/32856
FullText URL fulltext.pdf
Author Sumiyoshi, Kazuko| Kawata, Chieko| Shikata, Kenichi| Makino, Hirofumi|
Abstract <p>The aim of this study was to clarify the factors influencing the dietary behavior of patients with diabetic nephropathy. One hundred twenty-two patients with type 2 diabetes were recruited from the outpatients of Okayama University Hospital in Okayama, Japan. We performed a cross-sectional study using a questionnaire including 206 items among 18 categories as follows:background factors, coping behavior (coping scale), degree of uncertainty in illness (uncertainty scale), and dietary behavior. The data were analyzed by correlation analysis, t-test, one-way analysis of variance, Pearson correlation analysis, and multiple regression analysis. We found that those patients with microalbuminuria alone tended to recognize more mild about their kidney status than those with macroalbuminuria and chronic renal failure. We also found that common factors influencing the dietary behavior of diabetic patients with and without nephropathy are as follows:1. coping with the problem (beta0.342, p0.01);2. anxiety about prognosis (beta0.344, p0.01);3. sex (beta0.234, p0.05);4. uncertainty regarding treatment (beta0.377, p0.01);5. negative coping (beta0.354, p0.01);and 6. employment status (beta0.367, p0.01). Coping and uncertainty in illness had a significant relation to positive support and lack of support. To maintain appropriate dietary behavior in diabetic patients, medical staff need to determine what the social supports are important for the patient, and also to ensure good communication among healthcare personnel as well as positive support for patients and families.</p>
Keywords diabetic nephropathy dietary behavior coping uncertainty in illness social support
Amo Type Original Article
Published Date 2010-02
Publication Title Acta Medica Okayama
Volume volume64
Issue issue1
Publisher Okayama University Medical School
Start Page 39
End Page 47
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20200583
Web of Science KeyUT 000274868300006