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ID 30448
JaLCDOI
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Author
Haruta, Yuro
Takahashi, Isao
Sekito, Noriko
Miyamoto, Kanji
Shimamoto, Masaaki
Wakita, Yoshiharu
Kikkawa, Kiyoshi
Nakamura, Toru
Seto, Takumi
Yamashita, Jiro
Yorimiysu, Seiichi
Miyake, Susumu
Machida, Ken-ichi
Kimura, Ikuro
Abstract

A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs.

Keywords
variant Ph1 positive chronic myelocytic leukemia
bcr rearrangement
Amo Type
Article
Published Date
1990-10
Publication Title
Acta Medica Okayama
Volume
volume44
Issue
issue5
Publisher
Okayama University Medical School
Start Page
283
End Page
286
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT