JaLCDOI 10.18926/AMO/32175
FullText URL fulltext.pdf
Author Takahashi, Isao| Sano, Masayuki| Okamoto, Hideyuki| Shiromoto, Masayoshi| Nakamura, Toru| Ueno, Katsumi| Nakada, Hiroshi| Haruta, Yuro| Seto, Takumi| Yamashita, Jiro| Yorimitsu, Seiichi| Miyake, Susumu| Machida, Kenichi| Konda, Keiji| Tamura, Tetuo| Imajou, Kenji| Kimura, Ikuro|
Abstract <p>A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.</p>
Keywords recurrent thrombocytopenia HTLV-I HTLV-I carier
Amo Type Article
Published Date 1991-12
Publication Title Acta Medica Okayama
Volume volume45
Issue issue6
Publisher Okayama University Medical School
Start Page 445
End Page 449
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1781301
Web of Science KeyUT A1991GX45300007