JaLCDOI 10.18926/AMO/31107
FullText URL fulltext.pdf
Author Maekawa, Kiyoaki| Saito, Daiji| Kobayashi, Hiroo| Mizuo, Kouzo| Obayashi, Naotsugu| Uchida, Shinji| Haraoka, Shoichi|
Abstract <p>Nipradilol is a newly synthesized beta-blocker which has a propranolol-like structure and contains a nitrate moiety. To examine the effect of nipradilol on venous blood flow, a single oral dose of nipradilol (6 mg) and propranolol (20 mg) was administered in the same 15 normal volunteers on separate days. Peak flow velocities, flow velocity integrals, and the diameter of the right brachiocephalic vein were measured before and 2 h after drug administration using Doppler echocardiography. These two beta-blockers significantly decreased systolic blood pressure to the same extent as they did heart rate. Nipradilol dilated the venous diameter by 8% and decreased peak flow velocity by 8% during systole and 9% during diastole. The flow velocity integral in one cardiac cycle also decreased significantly by 14%. Propranolol, however, failed to modify these parameters. These results suggest that nipradilol decreased venous return through its nitroglycerin-like direct vasodilating action.</p>
Keywords Doppler echocardiography venous return nipradilol
Amo Type Article
Published Date 1994-04
Publication Title Acta Medica Okayama
Volume volume48
Issue issue2
Publisher Okayama University Medical School
Start Page 87
End Page 91
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8042538
Web of Science KeyUT A1994NJ77500004