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ID 13944
Eprint ID
13944
FullText URL
Thumnail 105_847.pdf 1.94 MB
Title Alternative
Prevalence and psychological features of fragile X syndrome in institutionalized male patients with mental retardation in Japan
Author
Murakami, Masae
Abstract
To determine the prevalence and psychological features of fragile X syndrome among Japanese, cytogenetic and psychological studies were conducted on 183 institutionalized male retardates. The induction of fra (X) (q27) by MEM-FA medium or fluorodeoxyuridine treatment revealed that 6 (3.3%) patients had fragile X syndrome. Psychological tests in the 6 patients with fragile X syndrome [Fra (X)], 6 control subjects with autism [AU] and 6 with simple mental retardation [MR] showed the following results : (1) on SM social maturity test, overall scores of social skills in Fra (X) were between those in AU and those patients in MR. Behavioral autonomy was much better in Fra (X) than in AU patients ; (2) on CLAC-Ⅱ behavior evaluation, Fra (X) patients had a tendency toward lower developmental levels in verbal and nonverbal expression as well as in handling compared to AU patients ; (3) on DSM-Ⅲ-R test, 3 of the 6 Fra (X) males met the criteria for autism. Fra (X) patients had fewer failures in recognizing others' existence or emotions, to develop relationships with others and to use language appropriately compared to AU patients, but had more defects in imitation of others and adaptation to environmental changes than MR patients. The similarity in the prevalence of the fragile X syndrome in the Japanese male retardates to that reported in Caucasians suggests that Fra (X) is a common genetic disorder affecting all ethnic populations. From the psychological findings, we concluded that Fra (X) patients have strong social aversion and defects in verbal and nonverbal expression which sometimes lead to autism.
Keywords
脆弱X症候群
精神発達遅滞
自閉性障害
葉酸欠乏培地
Note
原著
Published Date
1993-10
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
847
End Page
858
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/9-10/105_9-10_847/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma