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ID 31825
JaLCDOI
FullText URL
Author
Makita, Ryuji
Kokaze, Akatsuki
Ohtsu, Tadahiro
Ishikawa, Mamoru
Matsunaga, Naomi
Karita, Kanae
Yoshida, Masao
Tanaka, Nobukazu
Yamamoto, Minoru
Hayashi, Junichi
Takashima, Yutaka
Kitamoto, Kiyoshi
Abstract

Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p0.036 and p0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.

Keywords
daily alcohol consumption
longevity
total cholesterol
low-density lipoprotein cholesterol
NADH dehydrogenase
Amo Type
Original Article
Published Date
2009-12
Publication Title
Acta Medica Okayama
Volume
volume63
Issue
issue6
Publisher
Okayama University Medical School
Start Page
331
End Page
338
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT