Title Alternative Reactivity of secretory immunoglobulin A against gut bacteria is attenuated by high-fat diet consumption
FullText URL poalas_035_009_011.pdf
Author Tsuruta, Takeshi| MUHOMAH, Teresia Aluoch| Sonoyama, Kei| Nishino, Naoki|
Abstract Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2019-06
Volume volume35
Start Page 9
End Page 11
language 日本語
File Version publisher