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ID 31728
JaLCDOI
FullText URL
Author
Nomoto, Hiroyuki
Hirakawa, Satoshi
Ueki, Yasuyoshi
Abstract

We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.

Keywords
BRAL1
BCAN
FISH
schizophrenia
polymorphic marker
Amo Type
Article
Published Date
2002-02
Publication Title
Acta Medica Okayama
Volume
volume56
Issue
issue1
Publisher
Okayama University Medical School
Start Page
25
End Page
29
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT