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ID 16317
Eprint ID
16317
FullText URL
Thumnail 98_669.pdf 820 KB
Title Alternative
Studies on ethanol formation and its mechanism in corpses and stored biological samples
Author
Nagashima, Hiroshi
Abstract
The purpose of the present study was to investigate experimentally the formation of ethanol in corpses and stored biological samples important in medicolegal examination, and to study the mechanism of ethanol formation. In the tissues and bodily fluids of corpses, ethanol, n-propanol, iso-propanol, acetaldehyde, acetone and others may be formed to various degrees according to the postmortem conditions. The criteria of post-mortem ethanol formation are 20℃ and 24 hours of post-mortem time, and a significant amount of ethanol can be formed at higher temperatures and longer times. The presence of n-propanol in samples may be useful for ascertaining post-mortem ethanol formation. The amount of ethanol formed post-mortemly may be presumed to be under 20 times of the amount of n-propanol simultaneously detected. Post-mortem ethanol formation is not increased by ante-mortem ethanol intake. Ethanol may be produced in biological samples including cadaveric blood. Fresh aseptic blood is not conducive to ethanol formation within five days. The formation of n-propanol due to yeast in the stomach of corpses is lower than that due to bacteria in other organs and bodily fluids. The addition of antibiotics, which suppress the bacterial growth in the samples, and the addition of chemical inhibitors of ADH and ALDH contained in bacteria comletely blocked ethanol formation. It may be considered that ADH and ALDH in the bacteria in corpses produce ethanol from carbohydrates such as glucose and pyruvic acid through the reverse pathway of ethanol metabolism in living subjects.
Keywords
post-mortem ethanol
mechanism of ethanol formation
ethanol and organ storage
死体アルコール
Published Date
1986-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
669
End Page
685
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/98/7-8/98_7-8_669/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma