JaLCDOI 10.18926/AMO/32012
FullText URL fulltext.pdf
Author Ohke, Masashi| Tada, Shinya| Kataoka, Mikiko| Matsuo, Kiyoshi| Nabe, Makoto| Harada, Mine|
Abstract <p>This study investigated the relation between asthma attacks and levels of plasma fibronectin (FN) and serum eosinophilic cationic protein (ECP) in patients with bronchial asthma in order to clarify the role of FN in the airway inflammation of bronchial asthma. Plasma levels of FN were significantly higher (P &#60; 0.025) in patients with bronchial asthma than in healthy controls. They were also significantly higher (P &#60; 0.05) in non-atopic asthmatics than in atopic asthmatics. Furthermore, plasma FN was lower during the attack than the non-attack stage (P &#60; 0.025), and a significant increase of plasma FN was noted (P &#60; 0.05) in asthmatics who had more severe and more frequent attacks. Serum levels of ECP were significantly higher during the attack than the non-attack stage (P &#60; 0.005). An increase of plasma FN in the non-attack stage after attacks showed a significant correlation (P &#60; 0.05) with a decrease of serum ECP. These observations clearly indicate that the decrease in plasma FN associated with attacks is closely related to aggravation of airway inflammation, and that the increase in plasma FN in the non-attack stage reflects chronic airway inflammation. These results suggest that the fluctuation in plasma levels of FN may be one of the factors affecting allergic inflammation and attacks in bronchial asthma.</p>
Keywords adhesion molecule asthma attck bronchial asthma eosinophil cationic protein fibronectin
Amo Type Article
Published Date 2001-04
Publication Title Acta Medica Okayama
Volume volume55
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 96
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11332204
Web of Sience KeyUT 000168195700005
JaLCDOI 10.18926/AMO/32009
FullText URL fulltext.pdf
Author Ohke, Masashi| Tada, Shinya| Nabe, Makoto| Matsuo, Kiyoshi| Kataoka, Mikio| Harada, Mine|
Abstract <p>Allergic and chronic inflammation of the airway is regarded as the main pathogenesis of bronchial asthma, in which adhesion of inflammatory cells requires the expression of adhesion molecules. Thus, to clarify the role of fibronectin (FN) in the airway inflammation of bronchial asthma, FN levels in plasma and bronchoalveolar lavage fluid (BALF) from bronchial asthmatics were determined. FN concentrations in plasma and BALF were measured by enzyme-linked immunosorvent assay (ELISA) in 17 asthmatic patients and 10 healthy controls to elucidate the role of FN in allergic inflammation. The mean FN/albumin (Alb) level in the BALF of asthmatic patients was 2.973 micrograms/mg, which was significantly higher than that of healthy controls (0.727 microgram/mg). Non-atopic asthmatics showed a significantly higher level of FN in their BALF in comparison with atopic asthmatics, although the ratio of FN to albumin showed no significant difference. FN levels in BALF correlated significantly with total cell density (r = 0.71, P &#60; 0.05) and alveolar macrophage density (r = 0.64, P &#60; 0.05). FN levels in plasma did not correlate with those in BALF. In conclusion, increased FN in BALF, which was produced locally in the airways of asthmatic patients, is actively involved in the regulation of allergic inflammation.</p>
Keywords airway inflammation adhesion molecule bronchoalveolar lavage fluid bronchial asthma fibronectin
Amo Type Article
Published Date 2001-04
Publication Title Acta Medica Okayama
Volume volume55
Issue issue2
Publisher Okayama University Medical School
Start Page 83
End Page 89
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11332203
Web of Sience KeyUT 000168195700004
JaLCDOI 10.18926/AMO/31694
FullText URL fulltext.pdf
Author Takigawa, Tomoko| Kishimoto, Takumi| Nabe, Makoto| Nishide, Tadashi| Wang, Da-Hong| Seki, Akihiko| Uchida, Genkei| Kira, Shohei|
Abstract <p>This study involved the examination of 1,006 chest x-ray films of workers from the industries devoted to shipyard welding, stone grinding, and refractory crushing in southern Okayama prefecture. Of the reviewed films, analysis was focused on subjects with a profusion rate of 0/1 as well as pneumoconiotic subjects (exhibiting profusion rates of 1/0 or greater) in order to discover cases in the beginning stages. One-hundred-and-seventy-four films illustrated a profusion rate of 0/1 or greater, and the proportion of this profusion rate was revealed to be highest in shipyard welders. Even some workers under 40 years of age were found to have already developed pneumoconiosis. Of these 1,006 subjects, 30 volunteers permitted us to measure their personal dust exposure concentrations. The measured concentration of the shipyard welders' dust exposure (respirable dust; 3.3 86.3 mg/m3, total dust; 7.5-117.0 mg/m3) was higher than those of the other 2 industries. Statistical differences among the industries were observed in the respirable dust concentrations. A statistically significant positive correlation was demonstrated between the working duration in dusty environments and the rate of profusion. The present findings suggest the need for taking adequate measures in Okayama in order to prevent workers from developing, or to help retard the progression of, pneumoconiosis.</p>
Keywords pneumoconiosis profusion dust exposure shipyard welder Japan
Amo Type Article
Published Date 2002-12
Publication Title Acta Medica Okayama
Volume volume56
Issue issue6
Publisher Okayama University Medical School
Start Page 303
End Page 308
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12685859
Web of Sience KeyUT 000179959000005