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ID 48690
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Author
Ohara, Ichiyou
Ogata, Sho
Okusa, Yasushi
Ogawa, Tomomichi
Matsuzaki, Koji
Kaga, Hitoshi
Niihara, Naoko
Tominaga, Susumu
Hase, Kazuo
Abstract
In the duodenum, mixed exocrine-endocrine tumors exhibiting both neuroendocrine and glandular differentiations [cf. appendiceal goblet cell carcinoids (GCCs)] are rare. We present a Japanese case with a duodenal GCC that was found during pathologic examination of a gastrectomy specimen removed for gastric mucosal cancer. The tumor was widely distributed within both the first portion of the duodenum and the gastric antrum, although mucosal involvement was observed only in the duodenum. The tumor cells formed solid nests, trabeculae, or tubules, and some displayed a goblet cell appearance. They were immunoreactive against antibodies for both serotonin and somatostatin, and showed an argentaffin reaction (similar to a “midgut” enterochromaffin cell carcinoid). Ultra-structurally, the tumor cells had an amphicrine nature. Physicians encounter GCC in the duodenum only rarely, and its discovery may be incidental. Its diagnosis will be challenging and will require careful clinical and pathologic examinations.
Keywords
amphicrine tumor
duodenum
goblet cell carcinoid
serotonin
somatostatin
Amo Type
Case Report
Published Date
2012-08
Publication Title
Acta Medica Okayama
Volume
volume66
Issue
issue4
Publisher
Okayama University Medical School
Start Page
351
End Page
356
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2012 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT