このエントリーをはてなブックマークに追加
ID 14393
Eprint ID
14393
FullText URL
Thumnail 104_355.pdf 1.32 MB
Title Alternative
Superoxide dismutase activity in rheumatoid arthritis : its measurement and clinical implication
Author
Onoue, Jinichi
Abstract
In chronic inflammations of rheumatoid arthritis (RA), polynuclear leukocytes, macro-phages, synovial cells and other inflammatory cells release reactive oxygen species (ROS) and cause tissue impairment, and are regarded as the responsible agents in this pathological condition. In the present study, the electron spin resonance (ESR) method was used to measure superoxide dismutase (SOD) in 76 knee synovial fluid samples from rheumatoid knee joints and to compare the results with those of osteoarthritic knee joints and postraumatic arthritis. There was no significant difference in the SOD activity between PA and OA patients knee joint fluid, which was higher than that in patients with posttraumatic arthritis. The SOD activity in RA knee joint fluid showed no correlation with serum CRP (C-reactive protein) or erythrocyte sedimentation rate, indices of inflammation. According to Larsen's Grading of rtheumatoid knee radiography, patients with moderate RA changes (grade Ⅲ or Ⅳ) show higher SOD activity than patients with early (grade Ⅰ or Ⅱ) and terminal RA (grade Ⅴ). Our findings suggest that the SOD actvity in RA knee joint fluid is a valid index of articular destruction.
Keywords
superoxide dismutase
rheumatoid arthritis
electron spin resonance
Published Date
1992
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
355
End Page
364
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/3-4/104_3-4_355/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma