JaLCDOI 10.18926/AMO/31813
FullText URL fulltext.pdf
Author Kobayashi, Koichiro| Ogasawara, Masahiro| Kiyama, Yoshio| Miyazono, Takayoshi| Kagawa, Kumiko| Imai, Kiyotoshi| Hirano, Teiichi| Kobayashi, Naoki| Tanimoto, Mitsune| Kasai, Masaharu|
Abstract <p>A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. We made a clinical diagnosis of invasive pulmonary aspergillosis (IPA) based on a consolidation in the right upper lung field on a chest radiograph as well as a high level of serum beta-D-glucan (with no evidence of tuberculosis and candidiasis). We changed her treatment from micafungin to voriconazole. Later, we discovered an air-crescent sign by CT scan that supported the diagnosis of IPA. Following voriconazole treatment, clinical symptoms ceased and abnormal chest shadows improved gradually and concurrently with a recovery of neutrophils. IPA must be considered in immunocompromised patients with pulmonary infiltrates who do not respond to broad-spectrum antibiotics. Serological tests and CT findings can aid in early diagnosis of IPA, which, along with treatment for IPA, will improve clinical outcomes.</p>
Keywords invasive pulmonary aspergillosis voriconazole acute biphenotypic leukemia febrile neutropenia ?-D-glucan
Amo Type Case Report
Published Date 2009-08
Publication Title Acta Medica Okayama
Volume volume63
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 216
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19727206
Web of Science KeyUT 000269228400007