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ID 31107
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Author
Maekawa, Kiyoaki
Saito, Daiji
Kobayashi, Hiroo
Mizuo, Kouzo
Obayashi, Naotsugu
Uchida, Shinji
Haraoka, Shoichi
Abstract

Nipradilol is a newly synthesized beta-blocker which has a propranolol-like structure and contains a nitrate moiety. To examine the effect of nipradilol on venous blood flow, a single oral dose of nipradilol (6 mg) and propranolol (20 mg) was administered in the same 15 normal volunteers on separate days. Peak flow velocities, flow velocity integrals, and the diameter of the right brachiocephalic vein were measured before and 2 h after drug administration using Doppler echocardiography. These two beta-blockers significantly decreased systolic blood pressure to the same extent as they did heart rate. Nipradilol dilated the venous diameter by 8% and decreased peak flow velocity by 8% during systole and 9% during diastole. The flow velocity integral in one cardiac cycle also decreased significantly by 14%. Propranolol, however, failed to modify these parameters. These results suggest that nipradilol decreased venous return through its nitroglycerin-like direct vasodilating action.

Keywords
Doppler echocardiography
venous return
nipradilol
Amo Type
Article
Published Date
1994-04
Publication Title
Acta Medica Okayama
Volume
volume48
Issue
issue2
Publisher
Okayama University Medical School
Start Page
87
End Page
91
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT