JaLCDOI 10.18926/AMO/32608
FullText URL fulltext.pdf
Author Seno, Satimaru| Miyahara, Masanobu| Ochi, Osamu| Matsuoka, Kenichi| Toyama, Yuki| Shibata, Takashi|
Abstract <p>As has been well established, reticulocytes (RC) synthesize the species specific protein, globin, actively for about 24 hours or more till the time of their complete maturation1,2,3. This will be possible only in the presence of messenger RNA (m-RNA)4,5. Since the splendid hypothesis of m-RNA proposed by JACOB and MONOD6 for explaining the mechanism of the transfer of genetic information from nucleus to cytoplasm, it has largely been accepted through the numerous observations that followed7,8,9,10. However, the m-RNA hypothesis, which has been deduced by observing the protein synthesis in E. Coli, includes the meaning of labile RNA which is incessantly decomposed and newly synthesized to compensate the rapid degradation. As m-RNA cannot be synthesized in RC which have no detectable DNA, it has been supposed that the m-RNA of RC should be considerably stablell,12,13. Even in the denucleated cells, however, the RNA synthesis might be possible because Borsook reported the positive RNA synthesis of RC14, and this result has recently been reconfirmed by BURNY15.</p>
Amo Type Brief Note
Published Date 1963
Publication Title Acta Medicinae Okayama
Volume volume17
Issue issue5
Publisher Okayama University Medical School
Start Page 253
End Page 256
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14164122
NAID 120002312091