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ID 42610
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Thumnail 69_1997.pdf 833 KB
Title Alternative
Pharmacological Studies on Histaminase Activity in the Body Part 3 Distribution of Tissue Histaminase Activity in the Body, with Effect of Some Agents on It
Author
Ohkura, Yusuke
Abstract
Histaminase activity of several organs of a dog was determined by the volumetric method of Kapeller and Adler (1951), partly modified by the writer. In a normal dog, the activity of this eanzyme per gram of tissue was the highest in the kidney cortex, followed by the ileum and caecum, the duodenum showing lower activity (total layers used for the intestines), and the bladder, liver, stomach, lungs, skeletal muscles, and the skin all showed much lower values. Intravenous injection of a large dose of histamine or sinomenine caused decrease of histaminase activity only in the intestines and the liver, while daily subcutaneous injection of sinomenine for five days caused decrease of histaminase in the kidney cortex besides the above organs. Intravenous injection of peptone or corbicula extract, or anaphylactic shock caused marked decrease of histaminase activity in all these organs, but there was no such effect in ATP. Histamine, peptone and corbicula extract caused decrease of histaminase in the kidneys and intestines on perfusion of these organs. These facts indicate that the histaminase of these organs is capable of being released by certain substances and that these substances have a direct action of its own, besides that through the liberation of histamine that has the activity of liberating histaminase. Total adrenalectomy evidently decreased histaminase activity of the kidney cortex and the intestines.
Published Date
1957-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1997
End Page
2009
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/8/69_8_1997/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma