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ID 30942
JaLCDOI
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Author
Takasaki, Yohsuke
Kawakami, Norito
Tsuchiya, Masao
Ono, Yutaka
Nakane, Yoshibumi
Nakamura, Yosikazu
Tachimori, Hisateru
Iwata, Noboru
Uda, Hidenori
Nakane, Hideyuki
Watanabe, Makoto
Naganuma, Yoichi
Furukawa, Toshiaki
Hata, Yukihiro
Kobayashi, Masayo
Miyake, Yuko
Takeshima, Tadashi
Kikkawa, Takehiko
Abstract

We examined whether selected circulatory diseases (heart disease, stroke, diabetes and hypertension) were associated with an increased risk of major depression in the Japanese community population. Face-to-face household surveys were carried out in 7 areas, and a total of 2,436 persons participated (overall response rate: 58.4%) from 2002 to 2004. The WHO Composite International Diagnostic Interview 3.0 was used to diagnose major depression according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and additional interviews assessed the presence of circulatory diseases. Using data from a random subsample of the respondents (n=832), we conducted Cox proportional hazards models to calculate hazard ratios for the onset of major depression with comorbid circulatory diseases as a time-dependent covariate. Heart attack was significantly associated with the onset of major depression (hazard ratio [HR], 7.51 [95%Confidential Interval (CI), 1.36-41.45]) after adjusting for sex, birth cohort, smoking, alcohol intake, and education. Heart disease (HR, 2.12 [95% CI, 0.79-5.70]), diabetes (HR, 2.36 [95% CI, 0.42-13.34]) and hypertension (HR, 0.97 [95% CI, 0.37, 2.50]) were not significantly associated. There were no subjects who developed major depression after stroke. These results suggest that heart attack, and maybe also heart disease and diabetes, affect the onset of major depression.

Keywords
heart disease
circulatory diseases
major depression
community residents
world mental health
Amo Type
Original Article
Published Date
2008-08
Publication Title
Acta Medica Okayama
Volume
volume62
Issue
issue4
Publisher
Okayama University Medical School
Start Page
241
End Page
249
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT