JaLCDOI 10.18926/AMO/41323
FullText URL 64_6_375.pdf
Author Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.|
Abstract This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
Keywords diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss
Amo Type Original Article
Published Date 2010-12
Publication Title Acta Medica Okayama
Volume volume64
Issue issue6
Publisher Okayama University Medical School
Start Page 375
End Page 383
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21173807
Web of Science KeyUT 000285664200004
Author Kariya, Shin| Nishizaki, kazunori| Akagi, Hirofumi| Paparella, Michael M.|
Published Date 2004-11
Publication Title Journal of Laryngology & Otology
Volume volume118
Issue issue11
Content Type Journal Article