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ID 41323
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Author
Kariya, Shin Kakenhi
Cureoglu, Sebahattin
Fukushima, Hisaki
Morita, Norimasa
Baylan, Muzeyyen Y.
Maeda, Yukihide
Nishizaki, Kazunori
Paparella, Michael M.
Abstract
This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
Keywords
diabetes mellitus
temporal bone
cochlear spiral modiolar artery
hearing loss
Amo Type
Original Article
Published Date
2010-12
Publication Title
Acta Medica Okayama
Volume
volume64
Issue
issue6
Publisher
Okayama University Medical School
Start Page
375
End Page
383
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT