JaLCDOI 10.18926/AMO/53341
FullText URL 69_2_119.pdf
Author Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio|
Abstract We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.
Keywords catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension
Amo Type Case Report
Published Date 2015-04
Publication Title Acta Medica Okayama
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899634
Web of Sience KeyUT 000353181700007
JaLCDOI 10.18926/AMO/52145
FullText URL 68_1_53.pdf
Author Terasaka, Tomohiro| Ueta, Eijiro| Ebara, Hirotaka| Waseda, Koichi| Hanayama, Yoshihisa| Takaki, Akinobu| Kawabata, Tomoko| Sugiyama, Hitoshi| Hidan, Ko| Otsuka, Fumio|
Abstract A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.
Keywords adefovir dipivoxil (ADV) eldecalcitol Fanconi's syndrome hypophosphatemia osteomalacia
Amo Type Case Report
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 56
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553490
Title Alternative Peritoneal dialysis update
FullText URL 127_111.pdf
Author Sugiyama, Hitoshi|
Keywords 持続携行式腹膜透析(CAPD) 自動腹膜透析(APD) SMAP法 尿素Kt/V 腹膜平衡試験(peritoneal equilibration test:PET)
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 111
End Page 115
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.111
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.111
NAID 130005096252
JaLCDOI 10.18926/AMO/55434
FullText URL 71_5_369.pdf
Author Arata, Yuka| Tanabe, Katsuyuki| Hinamoto, Norikazu| Yamasaki, Hiroko| Sugiyama, Hitoshi| Maeshima, Yohei| Kanomata, Naoki| Sato, Yasufumi| Wada, Jun|
Abstract Several angiogenesis-related factors are known to play important roles in the pathogenesis of kidney disease. Vasohibin-2 (VASH-2) was recently reported as a novel proangiogenic factor. Although VASH-2 was demonstrated to accelerate tumor angiogenesis, its roles in non-tumor processes including renal disease have not been well elucidated yet. Here, we performed a retrospective study including an immunohistochemical analysis of human kidney biopsy specimens from 82 Japanese patients with a variety of kidney diseases, and we evaluated the correlations between the immunoreactivity of VASH-2 and the patients’ clinicopathological parameters. VASH-2 immunoreactivity was detected in varying degrees in renal tubules as well as in peritubular capillaries and vasa recta. The cortical and medullary tubule VASH-2+ scores were correlated with the presence of hypertension, and the medullary tubule VASH-2+ score was significantly correlated with the blood glucose (p=0.029, r=0.35) and hemoglobin A1c levels (p=0.0066, r=0.39). Moreover, decreased VASH-2+ scores in the vasa recta were associated with reduced renal function (p=0.0003). These results suggest that VASH-2 could play an important role in the pathogenesis of renal diseases, and that VASH-2 is closely associated with hypertension and impaired glucose tolerance.
Keywords vasohibin-2 kidney disease vasa recta medullary tubules
Amo Type Original Article
Published Date 2017-10
Publication Title Acta Medica Okayama
Volume volume71
Issue issue5
Publisher Okayama University Medical School
Start Page 369
End Page 380
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29042694
FullText URL Mod_Rheumatol_26_5_730.pdf
Author Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi|
Keywords Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis
Note This is an Accepted Manuscript of an article published by Taylor & Francis Group|
Published Date 2016-03-11
Publication Title Modern Rheumatology
Volume volume26
Issue issue5
Publisher Taylor & Francis
Start Page 730
End Page 737
ISSN 1439-7595
NCID AA1157187X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26873424
DOI 10.3109/14397595.2016.1140274
Web of Sience KeyUT 000393120600018
Related Url https://doi.org/10.3109/14397595.2016.1140274
JaLCDOI 10.18926/AMO/53117
FullText URL 69_1_1.pdf
Author Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi|
Abstract Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells.
Keywords prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus
Amo Type Original Article
Published Date 2015-02
Publication Title Acta Medica Okayama
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703166
Web of Sience KeyUT 000349740300001
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53128
JaLCDOI 10.18926/AMO/52788
FullText URL 68_4_219.pdf
Author Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi|
Abstract Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
Keywords chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145408
Web of Sience KeyUT 000340687500004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52824
Author Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
Published Date 2013-02-19
Publication Title PLoS ONE
Volume volume8
Issue issue2
Content Type Journal Article
Author Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi|
Published Date 2012-05-25
Publication Title BMC Nephrology
Volume volume13
Issue issue14
Content Type Journal Article
Author Nasu, Tatsuyo| Maeshima, Yohei| Kinomura, Masaru| Hirokoshi-Kawahara, Kumiko| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Sonoda, Hikaru| Sato, Yasufumi| Makino, Hirofumi|
Published Date 2011-04-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue1
Content Type Journal Article