JaLCDOI 10.18926/AMO/31651
FullText URL fulltext.pdf
Author Seven, Arzu| Tasan, Ertugrul| Hatemi, Husrev| Burcak, Gulden|
Abstract <p>This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant status parameters: glutathione (GSH), glutathione peroxidase (GSH-Px) and CuZn superoxide dismutase (CuZn SOD). Hyperthyroid patients were observed to have significantly higher TBARS, GSH and CuZn SOD levels than controls (P &#60; 0.05, P &#60; 0.001, P &#60; 0.001, respectively). PTU therapy caused a relief in oxidative stress as reflected by significantly decreased TBARS levels (P &#60; 0.001) and a selective modification in the antioxidant status parameters: significant decreases in GSH and CuZn SOD levels (P &#60; 0.001) and a significant increase in GSH Px (P &#60; 0.01) activity. Our findings suggest a selective modification of the antioxidative profile in hyperthyroidism. PTU should also be considered as an in vivo antioxidant, in addition to its antithyroid action.</p>
Keywords propylthiouracil hyperthyroidism glutathione glutathione peroxidase superoxide dismutase lipid peroxidation
Amo Type Article
Published Date 1999-02
Publication Title Acta Medica Okayama
Volume volume53
Issue issue1
Publisher Okayama University Medical School
Start Page 27
End Page 30
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000078897700005
JaLCDOI 10.18926/AMO/30797
FullText URL fulltext.pdf
Author Seymen, Oktay| Seven, Arzu| Candan, Gulden| Yigit, Gunnur| Hatemi, Sezer| Hatemi, Husrev|
Abstract <p>Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P &#60; 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P &#60; 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P &#60; 0.001) or the only L-thyroxine-administered hyperthyroid group (P &#60; 0.001, P &#60; 0.05, P &#60; 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.</p>
Keywords iron hyperthyroidism glutathione superoxide dismutase glutathione peroxidase
Amo Type Article
Published Date 1997-06
Publication Title Acta Medica Okayama
Volume volume51
Issue issue3
Publisher Okayama University Medical School
Start Page 129
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9227791
Web of Science KeyUT A1997XJ12700003