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ID 50972
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Author
Danura, Tetsuya
Shiraishi, Kensuke
Naito, Hiromichi
Mizoue, Ryoichi
Sato, Sachiko
Abstract
BACKGROUND: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. MATERIALS AND METHODS: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 µg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. RESULTS: There was no significant difference in onset time between the 2 groups (the control group vs. the esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P<0.05), and esmolol prolonged the duration of ischemic depolarization causing 50% neuronal damage from 4.97 to 6.34 minutes (P<0.05). Logistic regression curves also indicated that esmolol has a neuroprotective effect from 3.77 to 7.74 minutes of ischemic duration (P<0.05), and esmolol prolonged the ischemic duration causing 50% neuronal damage from 4.26 to 4.91 minutes (P<0.05).
Keywords
esmolol
[beta]-adrenoceptor
ischemic depolarization
neuroprotective effect
brain ischemia.
Published Date
2013-07
Publication Title
Journal of Neurosurgical Anesthesiology
Volume
volume25
Issue
issue3
Start Page
292
End Page
298
ISSN
0898-4921
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1097/ANA.0b013e31827fe3b1
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/50678
language
英語
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author
Refereed
True
DOI
PubMed ID