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Author
Yamazaki, Kenji Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wakabayashi, Hiroshi Department of Rheumatology, Okayama City Hospital
Suganami, Yu Department of General Internal medicine, Okayama City Hospital
Sano, Shinichi Department of General Internal medicine, Okayama City Hospital
Wakunami, Yu Department of General Internal medicine, Okayama City Hospital
Katayama, Takashi Department of General Internal medicine, Okayama City Hospital
Deguchi, Kentaro Department of Neurology, Okayama City Hospital
Nagotani, Shoko Department of Neurology, Okayama City Hospital
Kishida, Masayuki
Abstract
We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.
Keywords
dermatomyositis
anti-melanoma differentiation-associated gene 5 antibody
interstitial lung disease
pneumomediastinum
Amo Type
Case Report
Published Date
2017-08
Publication Title
Acta Medica Okayama
Volume
volume71
Issue
issue4
Publisher
Okayama University Medical School
Start Page
341
End Page
344
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2017 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID