JaLCDOI 10.18926/AMO/31634
FullText URL fulltext.pdf
Author Suzuki, Yasunori| Kohno, Yoshihiro| Takeda, Yoshihiro| Hiraki, Yoshio|
Abstract <p>To investigate the correlation between nuclear medicine parameters determined by technetium-99m-DTPA-galactosyl-human serum albumin (Tc-99m-GSA) and liver function tests, canonical correlation analysis was performed. Tc-99m-GSA studies were performed on 47 patients with hepatocellular carcinoma (HCC) who had undergone transcatheter arterial embolization (TAE). The nuclear medicine parameters LU15, HH15 and LHL15, which are results of nuclear imaging tests, were chosen in combination with the following liver function tests: the serum bilirubin level (T.Bil), the serum albumin level (Alb), serum cholinesterase activity (Ch-E), the clearance rate of indocyanine green (KICG), the hepaplastin test (HPT) and the prothrombin time (PT). The canonical correlation coefficient was 0.7345 and the upper tail probability was 0.00167. A significant correlation was observed between the two sets of variables. The high structural coefficients of Ch-E, KICG and HPT indicated a close relationship with the nuclear medicine parameters, supporting the notion that these nuclear medicine parameters are useful for the estimation of liver damage. The structural coefficients of the nuclear medicine parameters were also high, with LU15 being a parameter as useful as both HH15 and LHL15. T.Bil may evaluate a liver function that is not measured by nuclear imaging techniques, so we should take T.Bil results into account before considering TAE.</p>
Keywords Technetium-99m-DTPA-galactosyl-human serum albumin hepatocellular carcinoma transcatheter arterial embolization multivariate analysis
Amo Type Article
Published Date 1999-10
Publication Title Acta Medica Okayama
Volume volume53
Issue issue5
Publisher Okayama University Medical School
Start Page 225
End Page 232
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10561731
Web of Sience KeyUT 000083427100004
JaLCDOI 10.18926/AMO/31002
FullText URL fulltext.pdf
Author Miyazaki, Masahiro| Suzuki, Yasunori| Sato, Jiro|
Abstract <p>A method has been developed for the rapid preparation of single-cell suspensions from rat hepatocyte primary cultures on collagen substratum. Hepatocytes were adequately dissociated into single cells when the cultures were first treated with a combination of trypsin and ethylenediaminetetraacetic acid (EDTA) and then with collagenase. However, when the order was reversed, hepatocytes were inadequately dispersed. The possible mechanism of cell dissociation is discussed on the basis of the experimental data obtained.</p>
Keywords primary culture rat hepatocytes collagen substratum cell dissociation
Amo Type Article
Published Date 1988-12
Publication Title Acta Medica Okayama
Volume volume42
Issue issue6
Publisher Okayama University Medical School
Start Page 351
End Page 354
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2853558
Web of Sience KeyUT A1988R743300007