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ID 15885
Eprint ID
15885
FullText URL
Thumnail 99_273.pdf 2.83 MB
Title Alternative
Light and electron microscopic study of immunoglobulins on the surface of liver cells in type B chronic liver disease
Author
Sakamoto, Yuji
Abstract
The distribution of IgG, IgA and IgM was studied immunohistochemically in liver from 43 patients with type B chronic liver disease (chronic persistent hepatitis: 8 cases, chronic aggressive hepatitis 2A : 11 cases, chronic aggressive hepatitis 2B : 20 cases, liver cirrhosis : 4 cases) in relation to the hepatitis B virus-related antigen/antibody system. In 7 cases of chronic hepatitis, hepatocytes with IgG on the cell surface were scattered or clustered in the liver tissue. All 7 cases showed positive intrahepatic HBcAg and severe hepatitic activity. Immunoelectron microscopy revealed HBcAg to be localized in the membrane of the endoplasmic reticulum and on the cell surface of the hepatocytes. These findings suggest that the IgG on the hepatocytes may recognize HBcAg expressed on the surface of the hepatocytes. However, the cell surface IgG was also observed in liver tissue of chronic hepatitis patients which was obtained after acute exacerbation and in which HBcAg positive hepatocytes were scarcely seen. In such cases, the cell surface IgG may recognize HBV-related antigens other than HBcAg, neoantigens or liver specific membrane antigen.
Keywords
B型慢性肝疾患
酵素抗体法
免疫グロブリン
HBs抗原
HBc抗原
Published Date
1987-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
273
End Page
285
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_273/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma