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ID 51465
FullText URL
Author
Ogino, K.
Sakano, N.
Wang, D. H.
Yoshida, J.
Akazawa, Y.
Kanbara, S.
Inoue, K.
Kubo, M.
Takahashi, H.
Abstract
The usefulness of urinary hydrogen peroxide (H2O2) as an oxidative stress biomarker was evaluated in 766 healthy Japanese. The mean level of urinary concentrations of H2O2 was 5.66 +/- 8.27 mu mol/g creatinine, and was significantly higher in females than in males. Significant correlations of H2O2 were observed with age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), insulin, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and exercise habit in females. In both sexes, H2O2 showed a significant correlation with 8-OHdG. By a multiple logistic regression analysis, urinary H2O2 was positively associated with urinary 8-OHdG and TC and was inversely associated with insulin. By stratification of sex and age, the association of urinary H2O2 with TC was positive in both sexes under 50 years old and was inverse in males over 50 years old, and that with insulin was inverse in males over 50 years old and in females under 50 years old. Moreover, by stratification of sex and age, a positive association of H2O2 with exercise and an inverse association of H2O2 with alcohol consumption became clear in males under 50 years old, although there were no significant odds for H2O2 after adjustment for covariates. In conclusion, the present results suggest that urinary H2O2 is a useful biomarker for oxidative stress, showing an association with 8-OHdG, TC, and insulin independently.
Keywords
H2O2
8-OHdG
lifestyle
total cholesterol
exercise
Published Date
2013-03
Publication Title
Free Radical Research
Volume
volume47
Issue
issue3
Publisher
Informa Healthcare
Start Page
181
End Page
191
ISSN
1071-5762
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3109/10715762.2012.759218
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51463
language
英語
File Version
author
Refereed
True
DOI
Web of Sience KeyUT