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ID 50632
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Author
Takatani, Shogo
Ikeda, Tatsuya
Abstract
NIMA-related kinase 6 (NEK6) regulates cellular expansion and morphogenesis through microtubule organizaiton in Arabidopsis thaliana. Loss-of-function mutations in NEK6 (nek6/ibo1) cause ectopic outgrowth and microtubule disorganization in epidermal cells. We recently found that NEK6 forms homodimers and heterodimers with NEK4 and NEK5 to destabilize cortical microtubules possibly by direct binding to microtubules and the β-tubulin phosphorylation. Here, we identified a new allele of NEK6 and further analyzed the morphological phenotypes of nek6/ibo1 mutants, along with alleles of nek4 and nek5 mutants. Phenotypic analysis demonstrated that NEK6 is required for the directional growth of roots and hypocotyls, petiole elongation, cell file formation, and trichome morphogenesis. In addition, nek4, nek5, and nek6/ibo1 mutants were hypersensitive to microtubule inhibitors such as propyzamide and taxol. These results suggest that plant NEKs function in directional cell growth and organ development through the regulation of microtubule organization.
Keywords
Arabidopsis
NIMA-related kinase
directional growth
epidermis
microtubule
tubulin
Published Date
2012-12
Publication Title
Plant Signaling & Behavior
Volume
volume7
Issue
issue12
Start Page
1552
End Page
1555
ISSN
1559-2316
Content Type
Journal Article
language
英語
Copyright Holders
© 2012 Landes Bioscience
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Refereed
True
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PubMed ID