このエントリーをはてなブックマークに追加
ID 53601
FullText URL
Author
Takatani, Shogo
Otani, Kento
Kanazawa, Mai
Abstract
icrotubules are highly dynamic structures that control the spatiotemporal pattern of cell growth and division. Microtubule dynamics are regulated by reversible protein phosphorylation involving both protein kinases and phosphatases. Never in mitosis A (NIMA)-related kinases (NEKs) are a family of serine/threonine kinases that regulate microtubule-related mitotic events in fungi and animal cells (e.g. centrosome separation and spindle formation). Although plants contain multiple members of the NEK family, their functions remain elusive. Recent studies revealed that NEK6 of Arabidopsis thaliana regulates cell expansion and morphogenesis through β-tubulin phosphorylation and microtubule destabilization. In addition, plant NEK members participate in organ development and stress responses. The present phylogenetic analysis indicates that plant NEK genes are diverged from a single NEK6-like gene, which may share a common ancestor with other kinases involved in the control of microtubule organization. On the contrary, another mitotic kinase, polo-like kinase, might have been lost during the evolution of land plants. We propose that plant NEK members have acquired novel functions to regulate cell growth, microtubule organization, and stress responses.
Keywords
NIMA-related kinase
Phosphorylation
Tubulin
Microtubule
Cell expansion
Cell division
Note
The final publication is available at Springer via http://dx.doi.org/10.​1007/​s10265-015-0751-6 ,
Published Date
2015-11
Publication Title
Journal of Plant Research
Volume
volume128
Issue
issue6
Publisher
Springer Japan
Start Page
875
End Page
891
ISSN
0918-9440
NCID
AA10900218
Content Type
Journal Article
language
英語
Copyright Holders
The Botanical Society of Japan and Springer Japan
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT