JaLCDOI 10.18926/AMO/31216
FullText URL fulltext.pdf
Author Tai, Chiaki|
Abstract <p>According to the data obtained in this experiment by means of the geldiffusion technique, the specific antigen was not detected in MH134 ascitic tumor, comparing the anti-C3H liver sera with anti-MH 134 tumor sera, though a loss of organ specific antigen and weak antigenicity were found in MH134 tumor extract. In order to detect some qualitative alteration, supposedly a gain in antigenic components, the transplant rejection test was carried out. The result of this test indicates that the relative not absolute resistance could be induced to C3H mice by this prior sensitization with cell free active extract eluted from MH134 tumor tissue by Fluorocarbon treatment. During these experiments, it became clear that MH134 ascitic tumor cell has weak immunizing properties so that prolonged lapse of time and large dose of antigen are inevitably necessary. Moreover, through Fluorocarbon treatment of the tumor homogenate, the cellfree, serologically active antigen could be obtained, which will serve well for the induction of the isologous immunization.</p>
Amo Type Article
Published Date 1965-02
Publication Title Acta Medicinae Okayama
Volume volume19
Issue issue1
Publisher Okayama University Medical School
Start Page 41
End Page 54
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
NAID 120002313298
JaLCDOI 10.18926/AMO/31215
FullText URL fulltext.pdf
Author Tai, Chiaki|
Abstract <p>From the data presented in this communication, it might be concluded that a cancer specific substance, which can be demonstrated in gel diffusion, is present in human cancer tissue, common to various epithelial cancers of different individuals, although it may vary in its concentration. Needless to say, this substance is quite different from the so-called interspecies antigen or organ specific antigen, as proved by the present experiments. Furthermore, this substance can be eluted well by the Fluorocarbon treatment and it displays physically and chemically unstable characteristics. This substance is likely to be included in the microsome fraction and soluble fraction which was determined by gel diffusion technique. However, the association of this substance with other specific antigenic substances of human cancer, concerned with &#34;delayed type skin reaction&#34;, &#34;cytopathogenic antiserum against cancer cell&#34;, and &#34;complement fixing antibody in serum of patients with cancer&#34;, has not been elucidated in this study.</p>
Amo Type Article
Published Date 1965-02
Publication Title Acta Medicinae Okayama
Volume volume19
Issue issue1
Publisher Okayama University Medical School
Start Page 19
End Page 39
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4221698
NAID 120002313188