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ID 48962
JaLCDOI
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Thumnail 66_6_429.pdf 4.24 MB
Author
Wang, Feifei
Maeda, Nagamasa
Yasuhara, Takao
Kameda, Masahiro
Tsuru, Emi
Yamashita, Tatsuyuki
Shen, Yuan
Tsuda, Masayuki
Sagara, Yusuke
Abstract
Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
Keywords
umbilical cord blood
cell transplantation
neonatal hypoxic-ischemic brain injury
ischemic stroke
stem cells
Amo Type
Review
Published Date
2012-12
Publication Title
Acta Medica Okayama
Volume
volume66
Issue
issue6
Publisher
Okayama University Medical School
Start Page
429
End Page
434
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2012 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT