Author Tabuchi, Kazuo|
Published Date 1971-12
Publication Title Acta Medicinae Okayama
Volume volume25
Issue issue6
Content Type Journal Article
JaLCDOI 10.18926/AMO/32045
FullText URL fulltext.pdf
Author Tsuboi, Masahiro| Moriya, Yoshio| Tabuchi, Kazuo| Nishimoto, Akira|
Abstract <p>In order to locate the target cells for malignant transformation by BK virus (a human papova virus) in hamster brain, electron microscopic observation of tumor originally induced in hamster brain by BK virus was performed. With light microscopy, the BK virus-induced tumor (Vn 17) bore a close resemblance to human malignant ependymoma. Under the electron microscope, numerous microvilli and few cilia were visible on the surface of the tumor cells. These tumor cells were joined to each other by desmosomes. Gap junctions were not observed. Multilayered cuboidal cells were observed around the lumen and blood vessels in the tumor. With regard to fine structure, three types of Vn 17 cells were recognized; ependymal like cells, tanycytes with prominent cell processes, and undifferentiated cells with few cytoplasmic organelles. There was no basal lamina between the ependymal cells and the connective tissue stroma. The Vn 17 cells showed some similarity to the ultrastructural features of the epemdymal cells of newborn rabbits, suggesting that the target cells for Vn 17 may be cells related to ependyma. Malignant transformation of the cells would be initiated in the early stages after BK virus inoculation into the brain of newborn hamsters.</p>
Keywords elevtron microscopy experimental brain tumor BK virus
Amo Type Article
Published Date 1979-12
Publication Title Acta Medica Okayama
Volume volume33
Issue issue6
Publisher Okayama University Medical School
Start Page 423
End Page 430
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 231894
NAID 120002312316
JaLCDOI 10.18926/AMO/30542
FullText URL fulltext.pdf
Author Miyamoto, Kanji| Miyano, keiko| Tabuchi, Kazuo| Nishimoto, Akira| Yoshida, Haruhiko| Yumoto, Tokichi| Tanaka, Toshio|
Abstract Chromosome studies of a malignant lymphoma cell line derived from the brain were made by Q- and G-banding techniques. The modal number of chromosomes was 45. Complex structural rearrangements were present, but the 14q+ marker chromosome frequently seen in malignant lymphomas was not identified in the cell line. The main karyotype in cells analyzed was 45, X, -Y, del (2) (q21q23), t (3;?) (p25;?), t (p12;?), -8, 11q+, 18q+, +mar. Absence of the 14q+ may be explained by: firstly, clones which possessed 14q+ marker chromosome in brain tumor cells may have been selected out with increasing culture time and repeated passages; or secondly, the presence of the 14q+ marker chromosome depends on the type of lymphoma.
Keywords brain lymphoma tissue culture cell line chromosome negative 14q+.
Amo Type Brief Note
Published Date 1980-04
Publication Title Acta Medica Okayama
Volume volume34
Issue issue2
Publisher Okayama University Medical School
Start Page 117
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6450513
Web of Sience KeyUT A1980JY15600005
JaLCDOI 10.18926/AMO/30670
FullText URL fulltext.pdf
Author Harada, Yasuhiro| Tabuchi, Kazuo| Moriya, Yoshio| Furuta, Tomohisa| Kishikawa, Hidemi| Nishimoto, Akira|
Abstract <p>The amount of S-100 protein in rat brain embolized with carbon microspheres decreased in parallel with the development of cerebral edema as judged by water content, recovering to the normal range by 24h after embolization. These results suggest the participation of S-100 protein in the permeability characterisitics of nervous system capillaries known as the blood-brain barrier.</p>
Keywords S-100 protein blood-brain barrier cerebral edema
Amo Type Article
Published Date 1982-12
Publication Title Acta Medica Okayama
Volume volume36
Issue issue6
Publisher Okayama University Medical School
Start Page 447
End Page 451
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7158426
Web of Sience KeyUT A1982PW07500003